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Expression of Senescence Marker TIGIT Identifies Polyfunctional Donor-Reactive CD4+ T Cells Preferentially Lost After Kidney Transplantation
Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decreased risk for acute rejection in the years following kidney transplantation. The underlying mechanisms of donor-specific hyporesponsiveness (DSH) are largely unknown but may allow for lowering of immunosuppres...
Autores principales: | van der List, Amy C. J., Litjens, Nicolle H. R., Klepper, Mariska, Betjes, Michiel G. H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119878/ https://www.ncbi.nlm.nih.gov/pubmed/33995373 http://dx.doi.org/10.3389/fimmu.2021.656846 |
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