A Single Mutation in the Outer Lipid-Facing Helix of a Pentameric Ligand-Gated Ion Channel Affects Channel Function Through a Radially-Propagating Mechanism

Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic transmission and are crucial drug targets. Their gating mechanism is triggered by ligand binding in the extracellular domain that culminates in the opening of a hydrophobic gate in the transmembrane domain. This domain is made of fo...

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Detalles Bibliográficos
Autores principales: Crnjar, Alessandro, Mesoy, Susanne M., Lummis, Sarah C. R., Molteni, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119899/
https://www.ncbi.nlm.nih.gov/pubmed/33996899
http://dx.doi.org/10.3389/fmolb.2021.644720

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