Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice

CRISPR-based transcriptional activation is a powerful tool for functional gene interrogation; however, delivery difficulties have limited its applications in vivo. Here, we created a mouse model expressing all components of the CRISPR-Cas9 guide RNA-directed Synergistic Activation Mediator (SAM) fro...

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Detalles Bibliográficos
Autores principales: Hunt, Charleen, Hartford, Suzanne A., White, Derek, Pefanis, Evangelos, Hanna, Timothy, Herman, Clarissa, Wiley, Jarrell, Brown, Heather, Su, Qi, Xin, Yurong, Voronin, Dennis, Nguyen, Hien, Altarejos, Judith, Crosby, Keith, Haines, Jeffery, Cancelarich, Sarah, Drummond, Meghan, Moller-Tank, Sven, Malpass, Ryan, Buckley, Jacqueline, del Pilar Molina-Portela, Maria, Droguett, Gustavo, Frendewey, David, Chiao, Eric, Zambrowicz, Brian, Gong, Guochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119962/
https://www.ncbi.nlm.nih.gov/pubmed/33986266
http://dx.doi.org/10.1038/s41467-021-22932-4

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