Cargando…

Ubiquinone Binding and Reduction by Complex I—Open Questions and Mechanistic Implications

NADH: ubiquinone oxidoreductase (complex I) is the first enzyme complex of the respiratory chain. Complex I is a redox-driven proton pump that contributes to the proton motive force that drives ATP synthase. The structure of complex I has been analyzed by x-ray crystallography and electron cryo-micr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Galemou Yoga, Etienne, Schiller, Jonathan, Zickermann, Volker
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119997/ https://www.ncbi.nlm.nih.gov/pubmed/33996767 http://dx.doi.org/10.3389/fchem.2021.672851

Ejemplares similares

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
por: Cabrera-Orefice, Alfredo, et al.
Publicado: (2018)

Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
por: Galemou Yoga, Etienne, et al.
Publicado: (2020)

Binding of Natural Inhibitors to Respiratory Complex I
por: Schiller, Jonathan, et al.
Publicado: (2022)

High-resolution structure and dynamics of mitochondrial complex I—Insights into the proton pumping mechanism
por: Parey, Kristian, et al.
Publicado: (2021)

Reduction of Hydrophilic Ubiquinones by the Flavin in Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) and Production of Reactive Oxygen Species
por: King, Martin S., et al.
Publicado: (2009)

Respiratory complex I in mitochondrial membrane catalyzes oversized ubiquinones
por: Ikunishi, Ryo, et al.
Publicado: (2023)

Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling
por: Schiller, Jonathan, et al.
Publicado: (2022)

Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing
por: Ma, Wei, et al.
Publicado: (2013)

Quantification of NADH:ubiquinone oxidoreductase (complex I) content in biological samples
por: Ansari, Fariha, et al.
Publicado: (2021)

Diverse reaction behaviors of artificial ubiquinones in mitochondrial respiratory complex I
por: Uno, Shinpei, et al.
Publicado: (2022)

Computational Identification and Analysis of Ubiquinone-Binding Proteins
por: Lu, Chang, et al.
Publicado: (2020)

Accessory Subunits of the Matrix Arm of Mitochondrial Complex I with a Focus on Subunit NDUFS4 and Its Role in Complex I Function and Assembly
por: Kahlhöfer, Flora, et al.
Publicado: (2021)

Kinetic study of NADPH activation using ubiquinone-rhodol fluorescent probe and an Ir(III)-complex promoter at the cell interior
por: Komatsu, Hirokazu, et al.
Publicado: (2023)

Membrane-domain mutations in respiratory complex I impede catalysis but do not uncouple proton pumping from ubiquinone reduction
por: Jarman, Owen D, et al.
Publicado: (2022)

CORRIGENDUM: Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing
por: Ma, Wei, et al.
Publicado: (2013)

The Subunit Composition of Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) From Pichia pastoris
por: Bridges, Hannah R., et al.
Publicado: (2010)

Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy
por: Chung, Injae, et al.
Publicado: (2022)

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation
por: Kluckova, K, et al.
Publicado: (2015)

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency
por: Vos, Melissa, et al.
Publicado: (2017)

Uniporter substrate binding and transport: reformulating mechanistic questions
por: Zhang, Xuejun C., et al.
Publicado: (2016)

RegB Kinase Activity Is Controlled in Part by Monitoring the Ratio of Oxidized to Reduced Ubiquinones in the Ubiquinone Pool
por: Wu, Jiang, et al.
Publicado: (2010)

Mechanistic study of photocatalytic CO(2) reduction using a Ru(ii)–Re(i) supramolecular photocatalyst
por: Kamogawa, Kei, et al.
Publicado: (2021)

Mechanistic insight into electrocatalytic glyoxal reduction on copper and its relation to CO(2) reduction
por: Reichert, Andreas M., et al.
Publicado: (2022)

Interaction of methanol with the oxygen-evolving complex: atomistic models, channel identification, species dependence, and mechanistic implications
por: Retegan, Marius, et al.
Publicado: (2016)

Intriguing mechanistic labyrinths in gold(i) catalysis
por: Obradors, Carla, et al.
Publicado: (2014)

Cryo-EM structure of respiratory complex I at work
por: Parey, Kristian, et al.
Publicado: (2018)

Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors
por: Yamashita, Tetsuo, et al.
Publicado: (2018)

Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p
por: Jenkins, Bethany J., et al.
Publicado: (2016)

A Self‐Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone‐10 Cycling between Complex I and the Alternative Oxidase
por: Jones, Andrew J. Y., et al.
Publicado: (2015)

Realizing serine/threonine ligation: scope and limitations and mechanistic implication thereof
por: Wong, Clarence T. T., et al.
Publicado: (2014)

Mechanistic insights into the reductive dehydroxylation pathway for the biosynthesis of isoprenoids promoted by the IspH enzyme
por: Abdel-Azeim, Safwat, et al.
Publicado: (2015)

Nonspecific resistance to bacterial infections. Enhancement by ubiquinone-8
Publicado: (1978)

Phylogenetic ubiquity of the effects of altered ubiquinone biosynthesis on survival
por: Hekimi, Siegfried, et al.
Publicado: (2011)

Origin and Evolution of the Sodium -Pumping NADH: Ubiquinone Oxidoreductase
por: Reyes-Prieto, Adrian, et al.
Publicado: (2014)

Molecular Mechanisms Associated with the Induction of Ubiquinone by Peroxisome Proliferators
por: Khan, Seher Akhtar
Publicado: (2009)

Role of Subunit D in Ubiquinone-Binding Site of Vibrio cholerae NQR: Pocket Flexibility and Inhibitor Resistance
por: Raba, Daniel A., et al.
Publicado: (2019)

Visible light photocatalytic reduction of aldehydes by Rh(iii)–H: a detailed mechanistic study
por: Ghosh, T., et al.
Publicado: (2015)

Exploring the mechanistic role of alloying elements in copper-based electrocatalysts for the reduction of carbon dioxide to methane
por: Hao, Mingzhong, et al.
Publicado: (2023)

Robust Binding of Disulfide-Substituted Rhenium Bipyridyl Complexes for CO(2) Reduction on Gold Electrodes
por: Cattaneo, Mauricio, et al.
Publicado: (2020)

Mechanistic studies on the addition of hydrogen to iridaepoxide complexes with subsequent elimination of water
por: Doyle, Lauren E., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nbnlackt0gfaoc3kca4sknu1da