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TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma

Mutation of the telomerase reverse transcriptase (TERT) promoter has been demonstrated as an unfavorable prognostic marker in patients with isocitrate dehydrogenase wild-type (IDHwt) glioma. This study aimed to investigate the immune role of TERT promoter mutation status which could improve prognost...

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Autores principales: Gao, Mengqi, Lin, Yi, Liu, Xing, Zhao, Zheng, Zhu, Zhiyuan, Zhang, Hongbo, Ban, Yunchao, Bie, Yanan, He, Xiaozheng, Sun, Xiang, Zhang, Shizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119999/
https://www.ncbi.nlm.nih.gov/pubmed/33996815
http://dx.doi.org/10.3389/fcell.2021.654407
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author Gao, Mengqi
Lin, Yi
Liu, Xing
Zhao, Zheng
Zhu, Zhiyuan
Zhang, Hongbo
Ban, Yunchao
Bie, Yanan
He, Xiaozheng
Sun, Xiang
Zhang, Shizhong
author_facet Gao, Mengqi
Lin, Yi
Liu, Xing
Zhao, Zheng
Zhu, Zhiyuan
Zhang, Hongbo
Ban, Yunchao
Bie, Yanan
He, Xiaozheng
Sun, Xiang
Zhang, Shizhong
author_sort Gao, Mengqi
collection PubMed
description Mutation of the telomerase reverse transcriptase (TERT) promoter has been demonstrated as an unfavorable prognostic marker in patients with isocitrate dehydrogenase wild-type (IDHwt) glioma. This study aimed to investigate the immune role of TERT promoter mutation status which could improve prognostic prediction in IDHwt. TERT mutation status, IDH mutation, and 1p-19q codeletion status data were obtained from 614 glioma cases from the Cancer Genome Atlas, and 325 cases from the Chinese Glioma Genome Atlas. The same information was obtained from 49 clinical glioma tissues. TERT mutation is preferentially present in glioblastoma and IDH-wt gliomas and is associated with poor prognosis. Moreover, TERT mutation was associated with infiltration of neutrophils and expression of neutrophil chemokines. which might partially contribute to the poor outcome in IDH-wt glioma. Furthermore, patients with IDH-wt glioma did not harbor increased peripheral neutrophils, implying that the infiltrated neutrophil in the tumor environment might due to cytokine chemotaxis. In this study, we hereby propose that TERT mutation might be a molecular driver of the dysfunctional immune microenvironment in IDH-wt glioma. TERT mutation may be a potential immune therapeutic target for optimizing treatment combinations and patient selection for glioma immunotherapy.
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spelling pubmed-81199992021-05-15 TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma Gao, Mengqi Lin, Yi Liu, Xing Zhao, Zheng Zhu, Zhiyuan Zhang, Hongbo Ban, Yunchao Bie, Yanan He, Xiaozheng Sun, Xiang Zhang, Shizhong Front Cell Dev Biol Cell and Developmental Biology Mutation of the telomerase reverse transcriptase (TERT) promoter has been demonstrated as an unfavorable prognostic marker in patients with isocitrate dehydrogenase wild-type (IDHwt) glioma. This study aimed to investigate the immune role of TERT promoter mutation status which could improve prognostic prediction in IDHwt. TERT mutation status, IDH mutation, and 1p-19q codeletion status data were obtained from 614 glioma cases from the Cancer Genome Atlas, and 325 cases from the Chinese Glioma Genome Atlas. The same information was obtained from 49 clinical glioma tissues. TERT mutation is preferentially present in glioblastoma and IDH-wt gliomas and is associated with poor prognosis. Moreover, TERT mutation was associated with infiltration of neutrophils and expression of neutrophil chemokines. which might partially contribute to the poor outcome in IDH-wt glioma. Furthermore, patients with IDH-wt glioma did not harbor increased peripheral neutrophils, implying that the infiltrated neutrophil in the tumor environment might due to cytokine chemotaxis. In this study, we hereby propose that TERT mutation might be a molecular driver of the dysfunctional immune microenvironment in IDH-wt glioma. TERT mutation may be a potential immune therapeutic target for optimizing treatment combinations and patient selection for glioma immunotherapy. Frontiers Media S.A. 2021-04-30 /pmc/articles/PMC8119999/ /pubmed/33996815 http://dx.doi.org/10.3389/fcell.2021.654407 Text en Copyright © 2021 Gao, Lin, Liu, Zhao, Zhu, Zhang, Ban, Bie, He, Sun and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Gao, Mengqi
Lin, Yi
Liu, Xing
Zhao, Zheng
Zhu, Zhiyuan
Zhang, Hongbo
Ban, Yunchao
Bie, Yanan
He, Xiaozheng
Sun, Xiang
Zhang, Shizhong
TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma
title TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma
title_full TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma
title_fullStr TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma
title_full_unstemmed TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma
title_short TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma
title_sort tert mutation is accompanied by neutrophil infiltration and contributes to poor survival in isocitrate dehydrogenase wild-type glioma
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119999/
https://www.ncbi.nlm.nih.gov/pubmed/33996815
http://dx.doi.org/10.3389/fcell.2021.654407
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