Cargando…
TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma
Mutation of the telomerase reverse transcriptase (TERT) promoter has been demonstrated as an unfavorable prognostic marker in patients with isocitrate dehydrogenase wild-type (IDHwt) glioma. This study aimed to investigate the immune role of TERT promoter mutation status which could improve prognost...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119999/ https://www.ncbi.nlm.nih.gov/pubmed/33996815 http://dx.doi.org/10.3389/fcell.2021.654407 |
_version_ | 1783691974096715776 |
---|---|
author | Gao, Mengqi Lin, Yi Liu, Xing Zhao, Zheng Zhu, Zhiyuan Zhang, Hongbo Ban, Yunchao Bie, Yanan He, Xiaozheng Sun, Xiang Zhang, Shizhong |
author_facet | Gao, Mengqi Lin, Yi Liu, Xing Zhao, Zheng Zhu, Zhiyuan Zhang, Hongbo Ban, Yunchao Bie, Yanan He, Xiaozheng Sun, Xiang Zhang, Shizhong |
author_sort | Gao, Mengqi |
collection | PubMed |
description | Mutation of the telomerase reverse transcriptase (TERT) promoter has been demonstrated as an unfavorable prognostic marker in patients with isocitrate dehydrogenase wild-type (IDHwt) glioma. This study aimed to investigate the immune role of TERT promoter mutation status which could improve prognostic prediction in IDHwt. TERT mutation status, IDH mutation, and 1p-19q codeletion status data were obtained from 614 glioma cases from the Cancer Genome Atlas, and 325 cases from the Chinese Glioma Genome Atlas. The same information was obtained from 49 clinical glioma tissues. TERT mutation is preferentially present in glioblastoma and IDH-wt gliomas and is associated with poor prognosis. Moreover, TERT mutation was associated with infiltration of neutrophils and expression of neutrophil chemokines. which might partially contribute to the poor outcome in IDH-wt glioma. Furthermore, patients with IDH-wt glioma did not harbor increased peripheral neutrophils, implying that the infiltrated neutrophil in the tumor environment might due to cytokine chemotaxis. In this study, we hereby propose that TERT mutation might be a molecular driver of the dysfunctional immune microenvironment in IDH-wt glioma. TERT mutation may be a potential immune therapeutic target for optimizing treatment combinations and patient selection for glioma immunotherapy. |
format | Online Article Text |
id | pubmed-8119999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81199992021-05-15 TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma Gao, Mengqi Lin, Yi Liu, Xing Zhao, Zheng Zhu, Zhiyuan Zhang, Hongbo Ban, Yunchao Bie, Yanan He, Xiaozheng Sun, Xiang Zhang, Shizhong Front Cell Dev Biol Cell and Developmental Biology Mutation of the telomerase reverse transcriptase (TERT) promoter has been demonstrated as an unfavorable prognostic marker in patients with isocitrate dehydrogenase wild-type (IDHwt) glioma. This study aimed to investigate the immune role of TERT promoter mutation status which could improve prognostic prediction in IDHwt. TERT mutation status, IDH mutation, and 1p-19q codeletion status data were obtained from 614 glioma cases from the Cancer Genome Atlas, and 325 cases from the Chinese Glioma Genome Atlas. The same information was obtained from 49 clinical glioma tissues. TERT mutation is preferentially present in glioblastoma and IDH-wt gliomas and is associated with poor prognosis. Moreover, TERT mutation was associated with infiltration of neutrophils and expression of neutrophil chemokines. which might partially contribute to the poor outcome in IDH-wt glioma. Furthermore, patients with IDH-wt glioma did not harbor increased peripheral neutrophils, implying that the infiltrated neutrophil in the tumor environment might due to cytokine chemotaxis. In this study, we hereby propose that TERT mutation might be a molecular driver of the dysfunctional immune microenvironment in IDH-wt glioma. TERT mutation may be a potential immune therapeutic target for optimizing treatment combinations and patient selection for glioma immunotherapy. Frontiers Media S.A. 2021-04-30 /pmc/articles/PMC8119999/ /pubmed/33996815 http://dx.doi.org/10.3389/fcell.2021.654407 Text en Copyright © 2021 Gao, Lin, Liu, Zhao, Zhu, Zhang, Ban, Bie, He, Sun and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Gao, Mengqi Lin, Yi Liu, Xing Zhao, Zheng Zhu, Zhiyuan Zhang, Hongbo Ban, Yunchao Bie, Yanan He, Xiaozheng Sun, Xiang Zhang, Shizhong TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma |
title | TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma |
title_full | TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma |
title_fullStr | TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma |
title_full_unstemmed | TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma |
title_short | TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma |
title_sort | tert mutation is accompanied by neutrophil infiltration and contributes to poor survival in isocitrate dehydrogenase wild-type glioma |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119999/ https://www.ncbi.nlm.nih.gov/pubmed/33996815 http://dx.doi.org/10.3389/fcell.2021.654407 |
work_keys_str_mv | AT gaomengqi tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT linyi tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT liuxing tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT zhaozheng tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT zhuzhiyuan tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT zhanghongbo tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT banyunchao tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT bieyanan tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT hexiaozheng tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT sunxiang tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma AT zhangshizhong tertmutationisaccompaniedbyneutrophilinfiltrationandcontributestopoorsurvivalinisocitratedehydrogenasewildtypeglioma |