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Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB
The origin of genes has been a major topic of research for many years, albeit in some cases, it has been a difficult process to elucidate. Insightful is a recent publication that experimentally shows how one gene, linc-UR-UB was born. This gene is regulated in a complex manner in male germ cells dur...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120154/ https://www.ncbi.nlm.nih.gov/pubmed/33995491 http://dx.doi.org/10.3389/fgene.2021.661425 |
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author | Delihas, Nicholas |
author_facet | Delihas, Nicholas |
author_sort | Delihas, Nicholas |
collection | PubMed |
description | The origin of genes has been a major topic of research for many years, albeit in some cases, it has been a difficult process to elucidate. Insightful is a recent publication that experimentally shows how one gene, linc-UR-UB was born. This gene is regulated in a complex manner in male germ cells during spermatogenesis and is believed to participate in the regulation of levels of the ubiquitin specific peptidase 18 (USP18) mRNA. The process of formation of linc-UR-UB appears relatively simple. It involves a transcription read through from an upstream gene to a downstream functional element, the USP18 3' UTR sequence. This small element also shares the same sequence as the 3' ends of the lincRNA FAM247 family genes. In addition to linc-UR-UB, it is possible that other genes formed in a similar fashion that involves a genomic sequence read through to a functional element. |
format | Online Article Text |
id | pubmed-8120154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81201542021-05-15 Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB Delihas, Nicholas Front Genet Genetics The origin of genes has been a major topic of research for many years, albeit in some cases, it has been a difficult process to elucidate. Insightful is a recent publication that experimentally shows how one gene, linc-UR-UB was born. This gene is regulated in a complex manner in male germ cells during spermatogenesis and is believed to participate in the regulation of levels of the ubiquitin specific peptidase 18 (USP18) mRNA. The process of formation of linc-UR-UB appears relatively simple. It involves a transcription read through from an upstream gene to a downstream functional element, the USP18 3' UTR sequence. This small element also shares the same sequence as the 3' ends of the lincRNA FAM247 family genes. In addition to linc-UR-UB, it is possible that other genes formed in a similar fashion that involves a genomic sequence read through to a functional element. Frontiers Media S.A. 2021-04-30 /pmc/articles/PMC8120154/ /pubmed/33995491 http://dx.doi.org/10.3389/fgene.2021.661425 Text en Copyright © 2021 Delihas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Delihas, Nicholas Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB |
title | Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB |
title_full | Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB |
title_fullStr | Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB |
title_full_unstemmed | Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB |
title_short | Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB |
title_sort | birth of a regulatory long non-coding rna/gene, linc-ur-ub |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120154/ https://www.ncbi.nlm.nih.gov/pubmed/33995491 http://dx.doi.org/10.3389/fgene.2021.661425 |
work_keys_str_mv | AT delihasnicholas birthofaregulatorylongnoncodingrnagenelincurub |