Cargando…

Targeting hyperactive TGFBR2 for treating MYOCD deficient lung cancer

Purpose: Clinical success of cancer therapy is severely limited by drug resistance, attributed in large part to the loss of function of tumor suppressor genes (TSGs). Developing effective strategies to treat those tumors is challenging, but urgently needed in clinic. Experimental Design: MYOCD is a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Qian, Chen, Wensheng, Fan, Zhenzhen, Chen, Zhipeng, Liang, Jinxia, Zeng, Guandi, Liu, Lu, Liu, Wanting, Yang, Tong, Cao, Xin, Yu, Biao, Xu, Meng, Chen, Ye-Guang, Chen, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120205/ https://www.ncbi.nlm.nih.gov/pubmed/33995678 http://dx.doi.org/10.7150/thno.59816

Ejemplares similares

Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
por: Gao, Lei, et al.
Publicado: (2019)

GATA6 Exerts Potent Lung Cancer Suppressive Function by Inducing Cell Senescence
por: Chen, Wensheng, et al.
Publicado: (2020)

Inactivation of tumor suppressor gene Clusterin leads to hyperactivation of TAK1-NF-κB signaling axis in lung cancer cells and denotes a therapeutic opportunity
por: Chen, Zhipeng, et al.
Publicado: (2020)

Myocd regulates airway smooth muscle cell remodeling in response to chronic asthmatic injury
por: Yang, Qin, et al.
Publicado: (2023)

In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer
por: Liu, Lu, et al.
Publicado: (2022)

Requirement of miR-9-dependent regulation of Myocd in PASMCs phenotypic modulation and proliferation induced by hepatopulmonary syndrome rat serum
por: Xu, Duo, et al.
Publicado: (2015)

Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5
por: Belian, Elisa, et al.
Publicado: (2015)

Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury
por: Zhao, Hong, et al.
Publicado: (2021)

A tumor suppressor enhancing module orchestrated by GATA4 denotes a therapeutic opportunity for GATA4 deficient HCC patients
por: Lu, Feng, et al.
Publicado: (2020)

Discovery of Novel Inhibitor for WNT/β-Catenin Pathway by Tankyrase 1/2 Structure-Based Virtual Screening
por: Li, Bo, et al.
Publicado: (2020)

Cardiac Gene Activation Analysis in Mammalian Non-Myoblasic Cells by Nkx2-5, Tbx5, Gata4 and Myocd
por: Zhou, Lei, et al.
Publicado: (2012)

The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury
por: Zhang, Jingwei, et al.
Publicado: (2019)

Improvement of Heart Function After Transplantation of Encapsulated Stem Cells Induced with miR-1/Myocd in Myocardial Infarction Model of Rat
por: Khazaei, Samaneh, et al.
Publicado: (2021)

Luteolin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting TGFBR1 Signaling
por: Wu, Yu-Ting, et al.
Publicado: (2018)

Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs
por: Pasche, Boris, et al.
Publicado: (2010)

No major association between TGFBR1*6A and prostate cancer
por: Kaklamani, Virginia, et al.
Publicado: (2004)

Surgical Outcome and Histological Differences between Individuals with TGFBR1 and TGFBR2 Mutations in Loeys-Dietz Syndrome
por: Seike, Yoshimasa, et al.
Publicado: (2021)

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension
por: Sahoo, Sanghamitra, et al.
Publicado: (2016)

miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer
por: Li, Jialu, et al.
Publicado: (2015)

Sequencing of NOTCH1, GATA5, TGFBR1 and TGFBR2 genes in familial cases of bicuspid aortic valve
por: Foffa, Ilenia, et al.
Publicado: (2013)

In silico analysis of the potential effects of the disease-associated point mutations on the kinase activity of TGFBR1 and TGFBR2 receptors
por: Rougé, Pierre, et al.
Publicado: (2014)

Correction: miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer
por: Li, Jialu, et al.
Publicado: (2015)

Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer
por: Zhou, Qian, et al.
Publicado: (2021)

Identification of a Pathogenic TGFBR2 Variant in a Patient With Loeys–Dietz Syndrome
por: Luo, Xi, et al.
Publicado: (2020)

Associations of TGFBR1 and TGFBR2 gene polymorphisms with the risk of hypospadias: a case–control study in a Chinese population
por: Han, Xin-Rui, et al.
Publicado: (2017)

MicroRNA let‐7a regulates angiogenesis by targeting TGFBR3 mRNA
por: Wang, Shao, et al.
Publicado: (2018)

Estrogen-induced Tgfbr1 and Bmpr1a Expression Repressed via Estrogen Receptor Beta in MC3T3-E1 Cells
por: He, Han-Liang, et al.
Publicado: (2018)

MicroRNA let-7-TGFBR3 signalling regulates cardiomyocyte apoptosis after infarction
por: Chen, Chen-Yun, et al.
Publicado: (2019)

Dysregulation of the circ_0087502/miR-1179/TGFBR2 pathway supports gemcitabine resistance in pancreatic cancer
por: Chen, Mingliu, et al.
Publicado: (2023)

Retraction: Associations of TGFBR1 and TGFBR2 gene polymorphisms with the risk of hypospadias: a case-control study in a Chinese population
Publicado: (2022)

Lack of Association of rs1192415 in TGFBR3-CDC7 With Visual Field Progression: A Cohort Study in Chinese Open Angle Glaucoma Patients
por: Chen, Yuhong, et al.
Publicado: (2018)

Targeting BRAF-mutant tumours with TGFBR1 inhibitors
por: Spender, Lindsay C, et al.
Publicado: (2017)

Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p
por: Pan, Jiancheng, et al.
Publicado: (2022)

TGFBR1 variants TGFBR1(*)6A and Int7G24A are not associated with an increased familial colorectal cancer risk
por: Skoglund Lundin, J, et al.
Publicado: (2009)

Linc00462 promotes pancreatic cancer invasiveness through the miR-665/TGFBR1-TGFBR2/SMAD2/3 pathway
por: Zhou, Bin, et al.
Publicado: (2018)

Celecoxib inhibits the epithelial-to-mesenchymal transition in bladder cancer via the miRNA-145/TGFBR2/Smad3 axis
por: Liu, Xiaoqiang, et al.
Publicado: (2019)

Celecoxib inhibits the epithelial-to-mesenchymal transition in bladder cancer via the miRNA-145/TGFBR2/Smad3 axis
por: Liu, Xiaoqiang, et al.
Publicado: (2023)

Attention-deficit-hyperactivity disorder and reward deficiency syndrome
por: Blum, Kenneth, et al.
Publicado: (2008)

Tgfbr2 is required in Acan‐expressing cells for maintenance of the intervertebral and sternocostal joints
por: Alkhatib, Bashar, et al.
Publicado: (2018)

Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc
por: Sohn, Philip, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_admge41j0dhslbl41l36ct1m2g