A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment

Rationale: Alternative therapeutic strategies based on tumor-specific molecular targets are urgently needed for triple-negative breast cancer (TNBC). The protease cathepsin D (cath-D) is a marker of poor prognosis in TNBC and a tumor-specific extracellular target for antibody-based therapy. The iden...

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Detalles Bibliográficos
Autores principales: Alcaraz, Lindsay B, Mallavialle, Aude, David, Timothée, Derocq, Danielle, Delolme, Frédéric, Dieryckx, Cindy, Mollevi, Caroline, Boissière-Michot, Florence, Simony-Lafontaine, Joëlle, Du Manoir, Stanislas, Huesgen, Pitter F., Overall, Christopher M., Tartare-Deckert, Sophie, Jacot, William, Chardès, Thierry, Guiu, Séverine, Roger, Pascal, Reinheckel, Thomas, Moali, Catherine, Liaudet-Coopman, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120228/
https://www.ncbi.nlm.nih.gov/pubmed/33995652
http://dx.doi.org/10.7150/thno.58254

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