Cargando…

Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation

COVID-19 is a highly infectious respiratory virus, which can proliferate by invading the ACE2 receptor of host cells. Clinical studies have found that the virus can cause dyspnea, pneumonia and other cardiopulmonary system damage. In severe cases, it can lead to respiratory failure and even death. A...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Ming, Chen, Xuan, Shan, Jieling, Yang, Ruoyu, Guo, Qi, Bi, Xia, Xu, Ping, Shi, Xiangrong, Chu, Lixi, Wang, Liyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120309/
https://www.ncbi.nlm.nih.gov/pubmed/33995053
http://dx.doi.org/10.3389/fphar.2021.643619
_version_ 1783692039589724160
author Cai, Ming
Chen, Xuan
Shan, Jieling
Yang, Ruoyu
Guo, Qi
Bi, Xia
Xu, Ping
Shi, Xiangrong
Chu, Lixi
Wang, Liyan
author_facet Cai, Ming
Chen, Xuan
Shan, Jieling
Yang, Ruoyu
Guo, Qi
Bi, Xia
Xu, Ping
Shi, Xiangrong
Chu, Lixi
Wang, Liyan
author_sort Cai, Ming
collection PubMed
description COVID-19 is a highly infectious respiratory virus, which can proliferate by invading the ACE2 receptor of host cells. Clinical studies have found that the virus can cause dyspnea, pneumonia and other cardiopulmonary system damage. In severe cases, it can lead to respiratory failure and even death. Although there are currently no effective drugs or vaccines for the prevention and treatment of COVID-19, the patient’s prognosis recovery can be effectively improved by ameliorating the dysfunction of the respiratory system, cardiovascular systems, and immune function. Intermittent hypoxic preconditioning (IHP) as a new non-drug treatment has been applied in the clinical and rehabilitative practice for treating chronic obstructive pulmonary disease (COPD), diabetes, coronary heart disease, heart failure, hypertension, and other diseases. Many clinical studies have confirmed that IHP can improve the cardiopulmonary function of patients and increase the cardiorespiratory fitness and the tolerance of tissues and organs to ischemia. This article introduces the physiological and biochemical functions of IHP and proposes the potential application plan of IHP for the rehabilitation of patients with COVID-19, so as to provide a better prognosis for patients and speed up the recovery of the disease. The aim of this narrative review is to propose possible causes and pathophysiology of COVID-19 based on the mechanisms of the oxidative stress, inflammation, and immune response, and to provide a new, safe and efficacious strategy for the better rehabilitation from COVID-19.
format Online
Article
Text
id pubmed-8120309
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81203092021-05-15 Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation Cai, Ming Chen, Xuan Shan, Jieling Yang, Ruoyu Guo, Qi Bi, Xia Xu, Ping Shi, Xiangrong Chu, Lixi Wang, Liyan Front Pharmacol Pharmacology COVID-19 is a highly infectious respiratory virus, which can proliferate by invading the ACE2 receptor of host cells. Clinical studies have found that the virus can cause dyspnea, pneumonia and other cardiopulmonary system damage. In severe cases, it can lead to respiratory failure and even death. Although there are currently no effective drugs or vaccines for the prevention and treatment of COVID-19, the patient’s prognosis recovery can be effectively improved by ameliorating the dysfunction of the respiratory system, cardiovascular systems, and immune function. Intermittent hypoxic preconditioning (IHP) as a new non-drug treatment has been applied in the clinical and rehabilitative practice for treating chronic obstructive pulmonary disease (COPD), diabetes, coronary heart disease, heart failure, hypertension, and other diseases. Many clinical studies have confirmed that IHP can improve the cardiopulmonary function of patients and increase the cardiorespiratory fitness and the tolerance of tissues and organs to ischemia. This article introduces the physiological and biochemical functions of IHP and proposes the potential application plan of IHP for the rehabilitation of patients with COVID-19, so as to provide a better prognosis for patients and speed up the recovery of the disease. The aim of this narrative review is to propose possible causes and pathophysiology of COVID-19 based on the mechanisms of the oxidative stress, inflammation, and immune response, and to provide a new, safe and efficacious strategy for the better rehabilitation from COVID-19. Frontiers Media S.A. 2021-04-30 /pmc/articles/PMC8120309/ /pubmed/33995053 http://dx.doi.org/10.3389/fphar.2021.643619 Text en Copyright © 2021 Cai, Chen, Shan, Yang, Guo, Bi, Xu, Shi, Chu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Cai, Ming
Chen, Xuan
Shan, Jieling
Yang, Ruoyu
Guo, Qi
Bi, Xia
Xu, Ping
Shi, Xiangrong
Chu, Lixi
Wang, Liyan
Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation
title Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation
title_full Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation
title_fullStr Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation
title_full_unstemmed Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation
title_short Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation
title_sort intermittent hypoxic preconditioning: a potential new powerful strategy for covid-19 rehabilitation
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120309/
https://www.ncbi.nlm.nih.gov/pubmed/33995053
http://dx.doi.org/10.3389/fphar.2021.643619
work_keys_str_mv AT caiming intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation
AT chenxuan intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation
AT shanjieling intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation
AT yangruoyu intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation
AT guoqi intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation
AT bixia intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation
AT xuping intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation
AT shixiangrong intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation
AT chulixi intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation
AT wangliyan intermittenthypoxicpreconditioningapotentialnewpowerfulstrategyforcovid19rehabilitation