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The Absence of PTEN in Breast Cancer Is a Driver of MLN4924 Resistance

Background: Numerous studies have indicated that the neddylation pathway is closely associated with tumor development. MLN4924 (Pevonedistat), an inhibitor of the NEDD8-activating E1 enzyme, is considered a promising chemotherapeutic agent. Recently, we demonstrated that neddylation of the tumor sup...

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Detalles Bibliográficos
Autores principales:	Du, Meng-ge, Peng, Zhi-qiang, Gai, Wen-bin, Liu, Fan, Liu, Wei, Chen, Yu-jiao, Li, Hong-chang, Zhang, Xin, Liu, Cui Hua, Zhang, Ling-qiang, Jiang, Hong, Xie, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120322/ https://www.ncbi.nlm.nih.gov/pubmed/33996822 http://dx.doi.org/10.3389/fcell.2021.667435

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