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Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study
OBJECTIVE: Khat (Catha edulis Forssk) plant has been widely chewed for its psychostimulatory effects in the African and Arabian Peninsula, particularly in Yemen. Considering the khat leaves are gradually chewed without swallowing, while its active constituents are extracted into saliva, studying the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120822/ https://www.ncbi.nlm.nih.gov/pubmed/33985564 http://dx.doi.org/10.1186/s13104-021-05595-8 |
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author | Al-Qadhi, Gamilah Mubarak, Rabab |
author_facet | Al-Qadhi, Gamilah Mubarak, Rabab |
author_sort | Al-Qadhi, Gamilah |
collection | PubMed |
description | OBJECTIVE: Khat (Catha edulis Forssk) plant has been widely chewed for its psychostimulatory effects in the African and Arabian Peninsula, particularly in Yemen. Considering the khat leaves are gradually chewed without swallowing, while its active constituents are extracted into saliva, studying the effect of khat on salivary glands is necessary. This work is an extension of the previously published work that studied the effect of khat extract on the rats' submandibular salivary glands in terms of histological and immunohistochemical evaluations. The current research note aimed to better understand this effect on the ultrastructure of submandibular salivary gland cells by using transmission electron microscope. RESULTS: Oral administration of khat extract produced degenerative changes in the secretory and ductal cells of rats' submandibular salivary glands. These changes involved irregular boundaries of variable sized-nuclei, dilated RER, cytoplasmic vacuoles as well as swollen and degenerated mitochondria. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-021-05595-8. |
format | Online Article Text |
id | pubmed-8120822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81208222021-05-17 Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study Al-Qadhi, Gamilah Mubarak, Rabab BMC Res Notes Research Note OBJECTIVE: Khat (Catha edulis Forssk) plant has been widely chewed for its psychostimulatory effects in the African and Arabian Peninsula, particularly in Yemen. Considering the khat leaves are gradually chewed without swallowing, while its active constituents are extracted into saliva, studying the effect of khat on salivary glands is necessary. This work is an extension of the previously published work that studied the effect of khat extract on the rats' submandibular salivary glands in terms of histological and immunohistochemical evaluations. The current research note aimed to better understand this effect on the ultrastructure of submandibular salivary gland cells by using transmission electron microscope. RESULTS: Oral administration of khat extract produced degenerative changes in the secretory and ductal cells of rats' submandibular salivary glands. These changes involved irregular boundaries of variable sized-nuclei, dilated RER, cytoplasmic vacuoles as well as swollen and degenerated mitochondria. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-021-05595-8. BioMed Central 2021-05-13 /pmc/articles/PMC8120822/ /pubmed/33985564 http://dx.doi.org/10.1186/s13104-021-05595-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Note Al-Qadhi, Gamilah Mubarak, Rabab Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
title | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
title_full | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
title_fullStr | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
title_full_unstemmed | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
title_short | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
title_sort | qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120822/ https://www.ncbi.nlm.nih.gov/pubmed/33985564 http://dx.doi.org/10.1186/s13104-021-05595-8 |
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