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Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations
Among swine genetic markers, the highly polymorphic swine leukocyte antigen (SLA) is one of the key determinants, associated with not only immune responses but also reproductive performance and meat quality. The objective of this study was to characterize the SLA class I and II diversities in the co...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121083/ https://www.ncbi.nlm.nih.gov/pubmed/33996967 http://dx.doi.org/10.3389/fvets.2021.637682 |
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author | Techakriengkrai, Navapon Nedumpun, Teerawut Golde, William T. Suradhat, Sanipa |
author_facet | Techakriengkrai, Navapon Nedumpun, Teerawut Golde, William T. Suradhat, Sanipa |
author_sort | Techakriengkrai, Navapon |
collection | PubMed |
description | Among swine genetic markers, the highly polymorphic swine leukocyte antigen (SLA) is one of the key determinants, associated with not only immune responses but also reproductive performance and meat quality. The objective of this study was to characterize the SLA class I and II diversities in the commercial pig populations. In this study, a total number of 158 pigs (126 gilts and 32 boars) were randomly selected from different breeding herds of five major pig-producing companies, which covered ~70% of Thai swine production. The results indicate that a moderate level of SLA diversity was maintained in the Thai swine population, despite the performance-oriented breeding scheme. The highly common SLA class I alleles were SLA-1(*)08:XX, SLA-2(*)02:XX, and SLA-3(*)04:XX at a combined frequency of 30.1, 18.4, and 34.5%, respectively, whereas DRB1(*)04:XX, DQB1(*)02:XX and DQA(*)02:XX were the common class II alleles at 22.8, 33.3, and 38.6%, respectively. The haplotype Lr-32.0 (SLA-1(*)07:XX, SLA-2(*)02:XX, and SLA-3(*)04:XX) and Lr-0.23 (DRB1(*)10:XX, DQB1(*)06:XX, DQA(*) 01:XX) was the most common SLA class I and II haplotype, at 15.5 and 14.6%, respectively. Common class I and II haplotypes were also observed, which Lr-22.15 was the most predominant at 11.1%, followed by Lr-32.12 and Lr-4.2 at 10.8 and 7.9%, respectively. To our knowledge, this is the first report of SLA class I and II diversities in the commercial pigs in Southeast Asia. The information of the common SLA allele(s) in the population could facilitate swine genetic improvement and future vaccine design. |
format | Online Article Text |
id | pubmed-8121083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81210832021-05-15 Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations Techakriengkrai, Navapon Nedumpun, Teerawut Golde, William T. Suradhat, Sanipa Front Vet Sci Veterinary Science Among swine genetic markers, the highly polymorphic swine leukocyte antigen (SLA) is one of the key determinants, associated with not only immune responses but also reproductive performance and meat quality. The objective of this study was to characterize the SLA class I and II diversities in the commercial pig populations. In this study, a total number of 158 pigs (126 gilts and 32 boars) were randomly selected from different breeding herds of five major pig-producing companies, which covered ~70% of Thai swine production. The results indicate that a moderate level of SLA diversity was maintained in the Thai swine population, despite the performance-oriented breeding scheme. The highly common SLA class I alleles were SLA-1(*)08:XX, SLA-2(*)02:XX, and SLA-3(*)04:XX at a combined frequency of 30.1, 18.4, and 34.5%, respectively, whereas DRB1(*)04:XX, DQB1(*)02:XX and DQA(*)02:XX were the common class II alleles at 22.8, 33.3, and 38.6%, respectively. The haplotype Lr-32.0 (SLA-1(*)07:XX, SLA-2(*)02:XX, and SLA-3(*)04:XX) and Lr-0.23 (DRB1(*)10:XX, DQB1(*)06:XX, DQA(*) 01:XX) was the most common SLA class I and II haplotype, at 15.5 and 14.6%, respectively. Common class I and II haplotypes were also observed, which Lr-22.15 was the most predominant at 11.1%, followed by Lr-32.12 and Lr-4.2 at 10.8 and 7.9%, respectively. To our knowledge, this is the first report of SLA class I and II diversities in the commercial pigs in Southeast Asia. The information of the common SLA allele(s) in the population could facilitate swine genetic improvement and future vaccine design. Frontiers Media S.A. 2021-04-30 /pmc/articles/PMC8121083/ /pubmed/33996967 http://dx.doi.org/10.3389/fvets.2021.637682 Text en Copyright © 2021 Techakriengkrai, Nedumpun, Golde and Suradhat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Techakriengkrai, Navapon Nedumpun, Teerawut Golde, William T. Suradhat, Sanipa Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
title | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
title_full | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
title_fullStr | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
title_full_unstemmed | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
title_short | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
title_sort | diversity of the swine leukocyte antigen class i and ii in commercial pig populations |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121083/ https://www.ncbi.nlm.nih.gov/pubmed/33996967 http://dx.doi.org/10.3389/fvets.2021.637682 |
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