Cargando…

The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients

We assessed the impact of chest CT body composition parameters on outcomes and disease severity at hospital presentation of COVID-19 patients, focusing also on the possible mediation of body composition in the relationship between age and death in these patients. Chest CT scans performed at hospital...

Descripción completa

Detalles Bibliográficos
Autores principales: Besutti, Giulia, Pellegrini, Massimo, Ottone, Marta, Cantini, Michele, Milic, Jovana, Bonelli, Efrem, Dolci, Giovanni, Cassone, Giulia, Ligabue, Guido, Spaggiari, Lucia, Pattacini, Pierpaolo, Fasano, Tommaso, Canovi, Simone, Massari, Marco, Salvarani, Carlo, Guaraldi, Giovanni, Rossi, Paolo Giorgi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121324/
https://www.ncbi.nlm.nih.gov/pubmed/33989341
http://dx.doi.org/10.1371/journal.pone.0251768
_version_ 1783692317448732672
author Besutti, Giulia
Pellegrini, Massimo
Ottone, Marta
Cantini, Michele
Milic, Jovana
Bonelli, Efrem
Dolci, Giovanni
Cassone, Giulia
Ligabue, Guido
Spaggiari, Lucia
Pattacini, Pierpaolo
Fasano, Tommaso
Canovi, Simone
Massari, Marco
Salvarani, Carlo
Guaraldi, Giovanni
Rossi, Paolo Giorgi
author_facet Besutti, Giulia
Pellegrini, Massimo
Ottone, Marta
Cantini, Michele
Milic, Jovana
Bonelli, Efrem
Dolci, Giovanni
Cassone, Giulia
Ligabue, Guido
Spaggiari, Lucia
Pattacini, Pierpaolo
Fasano, Tommaso
Canovi, Simone
Massari, Marco
Salvarani, Carlo
Guaraldi, Giovanni
Rossi, Paolo Giorgi
author_sort Besutti, Giulia
collection PubMed
description We assessed the impact of chest CT body composition parameters on outcomes and disease severity at hospital presentation of COVID-19 patients, focusing also on the possible mediation of body composition in the relationship between age and death in these patients. Chest CT scans performed at hospital presentation by consecutive COVID-19 patients (02/27/2020-03/13/2020) were retrospectively reviewed to obtain pectoralis muscle density and total, visceral, and intermuscular adipose tissue areas (TAT, VAT, IMAT) at the level of T7-T8 vertebrae. Primary outcomes were: hospitalization, mechanical ventilation (MV) and/or death, death alone. Secondary outcomes were: C-reactive protein (CRP), oxygen saturation (SO2), CT disease extension at hospital presentation. The mediation of body composition in the effect of age on death was explored. Of the 318 patients included in the study (median age 65.7 years, females 37.7%), 205 (64.5%) were hospitalized, 68 (21.4%) needed MV, and 58 (18.2%) died. Increased muscle density was a protective factor while increased TAT, VAT, and IMAT were risk factors for hospitalization and MV/death. All these parameters except TAT had borderline effects on death alone. All parameters were associated with SO2 and extension of lung parenchymal involvement at CT; VAT was associated with CRP. Approximately 3% of the effect of age on death was mediated by decreased muscle density. In conclusion, low muscle quality and ectopic fat accumulation were associated with COVID-19 outcomes, VAT was associated with baseline inflammation. Low muscle quality partly mediated the effect of age on mortality.
format Online
Article
Text
id pubmed-8121324
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-81213242021-05-24 The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients Besutti, Giulia Pellegrini, Massimo Ottone, Marta Cantini, Michele Milic, Jovana Bonelli, Efrem Dolci, Giovanni Cassone, Giulia Ligabue, Guido Spaggiari, Lucia Pattacini, Pierpaolo Fasano, Tommaso Canovi, Simone Massari, Marco Salvarani, Carlo Guaraldi, Giovanni Rossi, Paolo Giorgi PLoS One Research Article We assessed the impact of chest CT body composition parameters on outcomes and disease severity at hospital presentation of COVID-19 patients, focusing also on the possible mediation of body composition in the relationship between age and death in these patients. Chest CT scans performed at hospital presentation by consecutive COVID-19 patients (02/27/2020-03/13/2020) were retrospectively reviewed to obtain pectoralis muscle density and total, visceral, and intermuscular adipose tissue areas (TAT, VAT, IMAT) at the level of T7-T8 vertebrae. Primary outcomes were: hospitalization, mechanical ventilation (MV) and/or death, death alone. Secondary outcomes were: C-reactive protein (CRP), oxygen saturation (SO2), CT disease extension at hospital presentation. The mediation of body composition in the effect of age on death was explored. Of the 318 patients included in the study (median age 65.7 years, females 37.7%), 205 (64.5%) were hospitalized, 68 (21.4%) needed MV, and 58 (18.2%) died. Increased muscle density was a protective factor while increased TAT, VAT, and IMAT were risk factors for hospitalization and MV/death. All these parameters except TAT had borderline effects on death alone. All parameters were associated with SO2 and extension of lung parenchymal involvement at CT; VAT was associated with CRP. Approximately 3% of the effect of age on death was mediated by decreased muscle density. In conclusion, low muscle quality and ectopic fat accumulation were associated with COVID-19 outcomes, VAT was associated with baseline inflammation. Low muscle quality partly mediated the effect of age on mortality. Public Library of Science 2021-05-14 /pmc/articles/PMC8121324/ /pubmed/33989341 http://dx.doi.org/10.1371/journal.pone.0251768 Text en © 2021 Besutti et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Besutti, Giulia
Pellegrini, Massimo
Ottone, Marta
Cantini, Michele
Milic, Jovana
Bonelli, Efrem
Dolci, Giovanni
Cassone, Giulia
Ligabue, Guido
Spaggiari, Lucia
Pattacini, Pierpaolo
Fasano, Tommaso
Canovi, Simone
Massari, Marco
Salvarani, Carlo
Guaraldi, Giovanni
Rossi, Paolo Giorgi
The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients
title The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients
title_full The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients
title_fullStr The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients
title_full_unstemmed The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients
title_short The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients
title_sort impact of chest ct body composition parameters on clinical outcomes in covid-19 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121324/
https://www.ncbi.nlm.nih.gov/pubmed/33989341
http://dx.doi.org/10.1371/journal.pone.0251768
work_keys_str_mv AT besuttigiulia theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT pellegrinimassimo theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT ottonemarta theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT cantinimichele theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT milicjovana theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT bonelliefrem theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT dolcigiovanni theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT cassonegiulia theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT ligabueguido theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT spaggiarilucia theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT pattacinipierpaolo theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT fasanotommaso theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT canovisimone theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT massarimarco theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT salvaranicarlo theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT guaraldigiovanni theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT rossipaologiorgi theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT theimpactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT besuttigiulia impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT pellegrinimassimo impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT ottonemarta impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT cantinimichele impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT milicjovana impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT bonelliefrem impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT dolcigiovanni impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT cassonegiulia impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT ligabueguido impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT spaggiarilucia impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT pattacinipierpaolo impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT fasanotommaso impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT canovisimone impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT massarimarco impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT salvaranicarlo impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT guaraldigiovanni impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT rossipaologiorgi impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients
AT impactofchestctbodycompositionparametersonclinicaloutcomesincovid19patients