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Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth

Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18–24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expen...

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Autores principales: Shivakumar, Nirupama, Sivadas, Ambily, Devi, Sarita, Jahoor, Farook, McLaughlin, John, Smith, Craig P., Kurpad, Anura V., Mukhopadhyay, Arpita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121364/
https://www.ncbi.nlm.nih.gov/pubmed/33989353
http://dx.doi.org/10.1371/journal.pone.0251803
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author Shivakumar, Nirupama
Sivadas, Ambily
Devi, Sarita
Jahoor, Farook
McLaughlin, John
Smith, Craig P.
Kurpad, Anura V.
Mukhopadhyay, Arpita
author_facet Shivakumar, Nirupama
Sivadas, Ambily
Devi, Sarita
Jahoor, Farook
McLaughlin, John
Smith, Craig P.
Kurpad, Anura V.
Mukhopadhyay, Arpita
author_sort Shivakumar, Nirupama
collection PubMed
description Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18–24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. Findings from this study indicate that child sex may be a critical modifier of the role of gut microbiota on childhood growth.
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spelling pubmed-81213642021-05-25 Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth Shivakumar, Nirupama Sivadas, Ambily Devi, Sarita Jahoor, Farook McLaughlin, John Smith, Craig P. Kurpad, Anura V. Mukhopadhyay, Arpita PLoS One Research Article Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18–24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. Findings from this study indicate that child sex may be a critical modifier of the role of gut microbiota on childhood growth. Public Library of Science 2021-05-14 /pmc/articles/PMC8121364/ /pubmed/33989353 http://dx.doi.org/10.1371/journal.pone.0251803 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Shivakumar, Nirupama
Sivadas, Ambily
Devi, Sarita
Jahoor, Farook
McLaughlin, John
Smith, Craig P.
Kurpad, Anura V.
Mukhopadhyay, Arpita
Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth
title Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth
title_full Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth
title_fullStr Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth
title_full_unstemmed Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth
title_short Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth
title_sort gut microbiota profiles of young south indian children: child sex-specific relations with growth
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121364/
https://www.ncbi.nlm.nih.gov/pubmed/33989353
http://dx.doi.org/10.1371/journal.pone.0251803
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