Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7–mediated Vangl ubiquitination and endoplasmic reticulum–associated degradation

The four-pass transmembrane proteins Vangl1 and Vangl2 are dedicated core components of Wnt/planar cell polarity (Wnt/PCP) signaling that critically regulate polarized cell behaviors in many morphological and physiological processes. Here, we found that the abundance of Vangl proteins is tightly con...

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Detalles Bibliográficos
Autores principales: Feng, Di, Wang, Jin, Yang, Wei, Li, Jingyu, Lin, Xiaochen, Zha, Fangzi, Wang, Xiaolu, Ma, Luyao, Choi, Nga Ting, Mii, Yusuke, Takada, Shinji, Huen, Michael S. Y., Guo, Yusong, Zhang, Liang, Gao, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121430/
https://www.ncbi.nlm.nih.gov/pubmed/33990333
http://dx.doi.org/10.1126/sciadv.abg2099

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