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Cork-in-bottle mechanism of inhibitor binding to mammalian complex I

Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a major contributor of free energy for oxidative phosphorylation, is increasingly recognized as a promising drug target for ischemia-reperfusion injury, metabolic disorders, and various cancers. Several pharmacologically relevant but structur...

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Detalles Bibliográficos
Autores principales:	Chung, Injae, Serreli, Riccardo, Cross, Jason B., Di Francesco, M. Emilia, Marszalek, Joseph R., Hirst, Judy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121435/ https://www.ncbi.nlm.nih.gov/pubmed/33990335 http://dx.doi.org/10.1126/sciadv.abg4000

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