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Flow Simulation in the Upper Respiratory Tract of Two Obstructive Sleep Apnea Patients with Successful and Failed Surgery

Obstructive sleep apnea (OSA) is a common disorder which may need to be treated by the upper respiratory tract (URT) surgery. To increase the success rate of the URT surgery, it is crucial to understand the flow features in the URT models. In this work, the turbulent flow characteristics in four 3D...

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Autores principales: Shao, Jiacun, Yan, Weiwei, Liu, Yang, Lu, Mingzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121595/
https://www.ncbi.nlm.nih.gov/pubmed/34040651
http://dx.doi.org/10.1155/2021/6683828
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author Shao, Jiacun
Yan, Weiwei
Liu, Yang
Lu, Mingzhen
author_facet Shao, Jiacun
Yan, Weiwei
Liu, Yang
Lu, Mingzhen
author_sort Shao, Jiacun
collection PubMed
description Obstructive sleep apnea (OSA) is a common disorder which may need to be treated by the upper respiratory tract (URT) surgery. To increase the success rate of the URT surgery, it is crucial to understand the flow features in the URT models. In this work, the turbulent flow characteristics in four 3D anatomically accurate URT models reconstructed from two OSA subjects with successful and failed surgery are numerically studied by the large-eddy simulation (LES) and unsteady Reynolds-averaged Navier-Stokes (RANS). The features of velocity fields, pressure fields, and wall shear stress fields as well as the spectral analysis of wall shear stress between successful and failed surgery are explored. The results indicate that LES is capable of capturing flow patterns and flow oscillation and is effective for OSA surgery prediction. Even if the unsteady RANS can obtain the correct pressure drop across the airways, it may not be appropriate to be used for surgery prediction. Moreover, it is found that the quality of oscillating signal of wall shear stress is a key factor in surgery prediction. In a successful surgery, the wall shear stress oscillation is always strong, and the oscillating signal can perform a dominant frequency near 3~5 Hz, while in a failed surgery it does not show this clear intrinsic property. The results not only will gain new insights in the URT surgical planning but also will improve the prediction of surgical outcome for OSA patients.
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spelling pubmed-81215952021-05-25 Flow Simulation in the Upper Respiratory Tract of Two Obstructive Sleep Apnea Patients with Successful and Failed Surgery Shao, Jiacun Yan, Weiwei Liu, Yang Lu, Mingzhen Comput Math Methods Med Research Article Obstructive sleep apnea (OSA) is a common disorder which may need to be treated by the upper respiratory tract (URT) surgery. To increase the success rate of the URT surgery, it is crucial to understand the flow features in the URT models. In this work, the turbulent flow characteristics in four 3D anatomically accurate URT models reconstructed from two OSA subjects with successful and failed surgery are numerically studied by the large-eddy simulation (LES) and unsteady Reynolds-averaged Navier-Stokes (RANS). The features of velocity fields, pressure fields, and wall shear stress fields as well as the spectral analysis of wall shear stress between successful and failed surgery are explored. The results indicate that LES is capable of capturing flow patterns and flow oscillation and is effective for OSA surgery prediction. Even if the unsteady RANS can obtain the correct pressure drop across the airways, it may not be appropriate to be used for surgery prediction. Moreover, it is found that the quality of oscillating signal of wall shear stress is a key factor in surgery prediction. In a successful surgery, the wall shear stress oscillation is always strong, and the oscillating signal can perform a dominant frequency near 3~5 Hz, while in a failed surgery it does not show this clear intrinsic property. The results not only will gain new insights in the URT surgical planning but also will improve the prediction of surgical outcome for OSA patients. Hindawi 2021-05-07 /pmc/articles/PMC8121595/ /pubmed/34040651 http://dx.doi.org/10.1155/2021/6683828 Text en Copyright © 2021 Jiacun Shao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shao, Jiacun
Yan, Weiwei
Liu, Yang
Lu, Mingzhen
Flow Simulation in the Upper Respiratory Tract of Two Obstructive Sleep Apnea Patients with Successful and Failed Surgery
title Flow Simulation in the Upper Respiratory Tract of Two Obstructive Sleep Apnea Patients with Successful and Failed Surgery
title_full Flow Simulation in the Upper Respiratory Tract of Two Obstructive Sleep Apnea Patients with Successful and Failed Surgery
title_fullStr Flow Simulation in the Upper Respiratory Tract of Two Obstructive Sleep Apnea Patients with Successful and Failed Surgery
title_full_unstemmed Flow Simulation in the Upper Respiratory Tract of Two Obstructive Sleep Apnea Patients with Successful and Failed Surgery
title_short Flow Simulation in the Upper Respiratory Tract of Two Obstructive Sleep Apnea Patients with Successful and Failed Surgery
title_sort flow simulation in the upper respiratory tract of two obstructive sleep apnea patients with successful and failed surgery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121595/
https://www.ncbi.nlm.nih.gov/pubmed/34040651
http://dx.doi.org/10.1155/2021/6683828
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