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Electromechanical coupling mechanism for activation and inactivation of an HCN channel

Pacemaker hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels exhibit a reversed voltage-dependent gating, activating by membrane hyperpolarization instead of depolarization. Sea urchin HCN (spHCN) channels also undergo inactivation with hyperpolarization which occurs only in the...

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Detalles Bibliográficos
Autores principales:	Dai, Gucan, Aman, Teresa K., DiMaio, Frank, Zagotta, William N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121817/ https://www.ncbi.nlm.nih.gov/pubmed/33990563 http://dx.doi.org/10.1038/s41467-021-23062-7

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