Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia

Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role in BC, the landscape and prognostic impact of these alterations remain elusive. Here, we comprehensively investigate genetic abnormalities in 136 B...

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Detalles Bibliográficos
Autores principales: Ochi, Yotaro, Yoshida, Kenichi, Huang, Ying-Jung, Kuo, Ming-Chung, Nannya, Yasuhito, Sasaki, Ko, Mitani, Kinuko, Hosoya, Noriko, Hiramoto, Nobuhiro, Ishikawa, Takayuki, Branford, Susan, Shanmuganathan, Naranie, Ohyashiki, Kazuma, Takahashi, Naoto, Takaku, Tomoiku, Tsuchiya, Shun, Kanemura, Nobuhiro, Nakamura, Nobuhiko, Ueda, Yasunori, Yoshihara, Satoshi, Bera, Rabindranath, Shiozawa, Yusuke, Zhao, Lanying, Takeda, June, Watatani, Yosaku, Okuda, Rurika, Makishima, Hideki, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Takaori-Kondo, Akifumi, Miyano, Satoru, Ogawa, Seishi, Shih, Lee-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121838/
https://www.ncbi.nlm.nih.gov/pubmed/33990592
http://dx.doi.org/10.1038/s41467-021-23097-w

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