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Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is su...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121846/ https://www.ncbi.nlm.nih.gov/pubmed/33990564 http://dx.doi.org/10.1038/s41467-021-22752-6 |
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| author | Karabegović, Irma Portilla-Fernandez, Eliana Li, Yang Ma, Jiantao Maas, Silvana C. E. Sun, Daokun Hu, Emily A. Kühnel, Brigitte Zhang, Yan Ambatipudi, Srikant Fiorito, Giovanni Huang, Jian Castillo-Fernandez, Juan E. Wiggins, Kerri L. de Klein, Niek Grioni, Sara Swenson, Brenton R. Polidoro, Silvia Treur, Jorien L. Cuenin, Cyrille Tsai, Pei-Chien Costeira, Ricardo Chajes, Veronique Braun, Kim Verweij, Niek Kretschmer, Anja Franke, Lude van Meurs, Joyce B. J. Uitterlinden, André G. de Knegt, Robert J. Ikram, M. Arfan Dehghan, Abbas Peters, Annette Schöttker, Ben Gharib, Sina A. Sotoodehnia, Nona Bell, Jordana T. Elliott, Paul Vineis, Paolo Relton, Caroline Herceg, Zdenko Brenner, Hermann Waldenberger, Melanie Rebholz, Casey M. Voortman, Trudy Pan, Qiuwei Fornage, Myriam Levy, Daniel Kayser, Manfred Ghanbari, Mohsen |
| author_facet | Karabegović, Irma Portilla-Fernandez, Eliana Li, Yang Ma, Jiantao Maas, Silvana C. E. Sun, Daokun Hu, Emily A. Kühnel, Brigitte Zhang, Yan Ambatipudi, Srikant Fiorito, Giovanni Huang, Jian Castillo-Fernandez, Juan E. Wiggins, Kerri L. de Klein, Niek Grioni, Sara Swenson, Brenton R. Polidoro, Silvia Treur, Jorien L. Cuenin, Cyrille Tsai, Pei-Chien Costeira, Ricardo Chajes, Veronique Braun, Kim Verweij, Niek Kretschmer, Anja Franke, Lude van Meurs, Joyce B. J. Uitterlinden, André G. de Knegt, Robert J. Ikram, M. Arfan Dehghan, Abbas Peters, Annette Schöttker, Ben Gharib, Sina A. Sotoodehnia, Nona Bell, Jordana T. Elliott, Paul Vineis, Paolo Relton, Caroline Herceg, Zdenko Brenner, Hermann Waldenberger, Melanie Rebholz, Casey M. Voortman, Trudy Pan, Qiuwei Fornage, Myriam Levy, Daniel Kayser, Manfred Ghanbari, Mohsen |
| author_sort | Karabegović, Irma |
| collection | PubMed |
| description | Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value <1.1×10(−7)), which annotated to the AHRR, F2RL3, FLJ43663, HDAC4, GFI1 and PHGDH genes. Among them, cg14476101 is significantly associated with expression of the PHGDH and risk of fatty liver disease. Knockdown of PHGDH expression in liver cells shows a correlation with expression levels of genes associated with circulating lipids, suggesting a role of PHGDH in hepatic-lipid metabolism. EWAS meta-analysis on tea consumption reveals no significant association, only two CpGs annotated to CACNA1A and PRDM16 genes show suggestive association (P-value <5.0×10(−6)). These findings indicate that coffee-associated changes in DNA methylation levels may explain the mechanism of action of coffee consumption in conferring risk of diseases. |
| format | Online Article Text |
| id | pubmed-8121846 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81218462021-05-18 Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption Karabegović, Irma Portilla-Fernandez, Eliana Li, Yang Ma, Jiantao Maas, Silvana C. E. Sun, Daokun Hu, Emily A. Kühnel, Brigitte Zhang, Yan Ambatipudi, Srikant Fiorito, Giovanni Huang, Jian Castillo-Fernandez, Juan E. Wiggins, Kerri L. de Klein, Niek Grioni, Sara Swenson, Brenton R. Polidoro, Silvia Treur, Jorien L. Cuenin, Cyrille Tsai, Pei-Chien Costeira, Ricardo Chajes, Veronique Braun, Kim Verweij, Niek Kretschmer, Anja Franke, Lude van Meurs, Joyce B. J. Uitterlinden, André G. de Knegt, Robert J. Ikram, M. Arfan Dehghan, Abbas Peters, Annette Schöttker, Ben Gharib, Sina A. Sotoodehnia, Nona Bell, Jordana T. Elliott, Paul Vineis, Paolo Relton, Caroline Herceg, Zdenko Brenner, Hermann Waldenberger, Melanie Rebholz, Casey M. Voortman, Trudy Pan, Qiuwei Fornage, Myriam Levy, Daniel Kayser, Manfred Ghanbari, Mohsen Nat Commun Article Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value <1.1×10(−7)), which annotated to the AHRR, F2RL3, FLJ43663, HDAC4, GFI1 and PHGDH genes. Among them, cg14476101 is significantly associated with expression of the PHGDH and risk of fatty liver disease. Knockdown of PHGDH expression in liver cells shows a correlation with expression levels of genes associated with circulating lipids, suggesting a role of PHGDH in hepatic-lipid metabolism. EWAS meta-analysis on tea consumption reveals no significant association, only two CpGs annotated to CACNA1A and PRDM16 genes show suggestive association (P-value <5.0×10(−6)). These findings indicate that coffee-associated changes in DNA methylation levels may explain the mechanism of action of coffee consumption in conferring risk of diseases. Nature Publishing Group UK 2021-05-14 /pmc/articles/PMC8121846/ /pubmed/33990564 http://dx.doi.org/10.1038/s41467-021-22752-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Karabegović, Irma Portilla-Fernandez, Eliana Li, Yang Ma, Jiantao Maas, Silvana C. E. Sun, Daokun Hu, Emily A. Kühnel, Brigitte Zhang, Yan Ambatipudi, Srikant Fiorito, Giovanni Huang, Jian Castillo-Fernandez, Juan E. Wiggins, Kerri L. de Klein, Niek Grioni, Sara Swenson, Brenton R. Polidoro, Silvia Treur, Jorien L. Cuenin, Cyrille Tsai, Pei-Chien Costeira, Ricardo Chajes, Veronique Braun, Kim Verweij, Niek Kretschmer, Anja Franke, Lude van Meurs, Joyce B. J. Uitterlinden, André G. de Knegt, Robert J. Ikram, M. Arfan Dehghan, Abbas Peters, Annette Schöttker, Ben Gharib, Sina A. Sotoodehnia, Nona Bell, Jordana T. Elliott, Paul Vineis, Paolo Relton, Caroline Herceg, Zdenko Brenner, Hermann Waldenberger, Melanie Rebholz, Casey M. Voortman, Trudy Pan, Qiuwei Fornage, Myriam Levy, Daniel Kayser, Manfred Ghanbari, Mohsen Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption |
| title | Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption |
| title_full | Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption |
| title_fullStr | Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption |
| title_full_unstemmed | Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption |
| title_short | Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption |
| title_sort | epigenome-wide association meta-analysis of dna methylation with coffee and tea consumption |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121846/ https://www.ncbi.nlm.nih.gov/pubmed/33990564 http://dx.doi.org/10.1038/s41467-021-22752-6 |
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