Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer

Trastuzumab is the backbone of HER2-directed gastric cancer therapy, but poor patient response due to insufficient cell sensitivity and drug resistance remains a clinical challenge. Here, we report that HER2 is involved in cell mitotic promotion for tumorigenesis by hyperactivating a crucial HER2-SH...

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Detalles Bibliográficos
Autores principales: Shi, Wengui, Zhang, Gengyuan, Ma, Zhijian, Li, Lianshun, Liu, Miaomiao, Qin, Long, Yu, Zeyuan, Zhao, Lei, Liu, Yang, Zhang, Xue, Qin, Junjie, Ye, Huili, Jiang, Xiangyan, Zhou, Huinian, Sun, Hui, Jiao, Zuoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121856/
https://www.ncbi.nlm.nih.gov/pubmed/33990570
http://dx.doi.org/10.1038/s41467-021-23053-8

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