STAT1 gain-of-function heterozygous cell models reveal diverse interferon-signature gene transcriptional responses

Signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) is an autosomal dominant immune disorder marked by wide infectious predisposition, autoimmunity, vascular disease, and malignancy. Its molecular hallmark, elevated phospho-STAT1 (pSTAT1) following interferon (IFN) stim...

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Detalles Bibliográficos
Autores principales: Scott, Ori, Lindsay, Kyle, Erwood, Steven, Mollica, Antonio, Roifman, Chaim M., Cohn, Ronald D., Ivakine, Evgueni A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121859/
https://www.ncbi.nlm.nih.gov/pubmed/33990617
http://dx.doi.org/10.1038/s41525-021-00196-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121859/
https://www.ncbi.nlm.nih.gov/pubmed/33990617
http://dx.doi.org/10.1038/s41525-021-00196-7

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