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Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells
Pancreatic islets adapt to insulin resistance of pregnancy by up regulating β-cell mass and increasing insulin secretion. Previously, using a transgenic mouse with global, heterozygous deletion of prolactin receptor (Prlr(+/−)), we found Prlr signaling is important for this adaptation. However, sinc...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121891/ https://www.ncbi.nlm.nih.gov/pubmed/33990661 http://dx.doi.org/10.1038/s41598-021-89745-9 |