trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway

trans-Fatty acids (TFAs) are food-derived fatty acids associated with various diseases including cardiovascular diseases. However, the underlying etiology is poorly understood. Here, we show a pro-apoptotic mechanism of TFAs such as elaidic acid (EA), in response to DNA interstrand crosslinks (ICLs)...

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Detalles Bibliográficos
Autores principales: Hirata, Yusuke, Takahashi, Miki, Yamada, Yuto, Matsui, Ryosuke, Inoue, Aya, Ashida, Ryo, Noguchi, Takuya, Matsuzawa, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121903/
https://www.ncbi.nlm.nih.gov/pubmed/33990641
http://dx.doi.org/10.1038/s41598-021-89506-8

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