Cargando…

Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity

BACKGROUND & AIMS: The multiple vital functions of the human liver are performed by highly specialised parenchymal and non-parenchymal cells organised in complex collaborative sinusoidal units. Although crucial for homeostasis, the cellular make-up of the human liver remains to be fully elucidat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Payen, Valéry L., Lavergne, Arnaud, Alevra Sarika, Niki, Colonval, Megan, Karim, Latifa, Deckers, Manon, Najimi, Mustapha, Coppieters, Wouter, Charloteaux, Benoît, Sokal, Etienne M., El Taghdouini, Adil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121977/ https://www.ncbi.nlm.nih.gov/pubmed/34027339 http://dx.doi.org/10.1016/j.jhepr.2021.100278

Ejemplares similares

In vitro reversion of activated primary human hepatic stellate cells
por: El Taghdouini, Adil, et al.
Publicado: (2015)

Human Liver-Derived Extracellular Matrix for the Culture of Distinct Human Primary Liver Cells
por: Alevra Sarika, Niki, et al.
Publicado: (2020)

Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation
por: Najimi, Mustapha, et al.
Publicado: (2017)

Gene Expression Profiling and Secretome Analysis Differentiate Adult-Derived Human Liver Stem/Progenitor Cells and Human Hepatic Stellate Cells
por: Berardis, Silvia, et al.
Publicado: (2014)

Mitochondrial uncouplers inhibit hepatic stellate cell activation
por: Guimarães, Eduardo L, et al.
Publicado: (2012)

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells
por: El Taghdouini, Adil, et al.
Publicado: (2015)

Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells
por: Coll, Mar, et al.
Publicado: (2015)

Detection and identification of transgenic events by next generation sequencing combined with enrichment technologies
por: Debode, Frédéric, et al.
Publicado: (2019)

Comprehensive Screening of Cell Surface Markers Expressed by Adult-Derived Human Liver Stem/Progenitor Cells Harvested at Passage 5: Potential Implications for Engraftment
por: Dollet, Pierre-Edouard, et al.
Publicado: (2016)

Bivalirudin in Combination with Heparin to Control Mesenchymal Cell Procoagulant Activity
por: Stephenne, Xavier, et al.
Publicado: (2012)

SNP-based quantitative deconvolution of biological mixtures: application to the detection of cows with subclinical mastitis by whole-genome sequencing of tank milk
por: Coppieters, Wouter, et al.
Publicado: (2020)

Human Umbilical Cord Matrix Stem Cells Maintain Multilineage Differentiation Abilities and Do Not Transform during Long-Term Culture
por: Scheers, Isabelle, et al.
Publicado: (2013)

Age‐dependent glycosylation of the sodium taurocholate cotransporter polypeptide: From fetal to adult human livers
por: Sargiacomo, Camillo, et al.
Publicado: (2018)

Human Allogeneic Liver-Derived Progenitor Cells Significantly Improve NAFLD Activity Score and Fibrosis in Late-Stage NASH Animal Model
por: Najimi, Mustapha, et al.
Publicado: (2022)

Hepatocytic Differentiation Potential of Human Fetal Liver Mesenchymal Stem Cells: In Vitro and In Vivo Evaluation
por: El-Kehdy, Hoda, et al.
Publicado: (2016)

Immunoprofiling of Adult-Derived Human Liver Stem/Progenitor Cells: Impact of Hepatogenic Differentiation and Inflammation
por: El-Kehdy, Hoda, et al.
Publicado: (2017)

Acute Liver Toxicity Modifies Protein Expression of Glutamate Transporters in Liver and Cerebellar Tissue
por: Jiménez-Torres, Catya, et al.
Publicado: (2021)

High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in Pex1-G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment
por: Demaret, Tanguy, et al.
Publicado: (2020)

Premature senescence of the liver in Alagille patients
por: Jannone, Giulia, et al.
Publicado: (2023)

Evaluation of Strategies Aimed at Improving Liver Progenitor Cell Rolling and Subsequent Adhesion to the Endothelium
por: Dollet, Pierre Edouard, et al.
Publicado: (2020)

Inflammation Differentially Modulates the Biological Features of Adult Derived Human Liver Stem/Progenitor Cells
por: El-Kehdy, Hoda, et al.
Publicado: (2020)

MPV17 does not control cancer cell proliferation
por: Canonne, Morgane, et al.
Publicado: (2020)

Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry
por: Sargiacomo, Camillo, et al.
Publicado: (2017)

Detection of Human Microchimerism following Allogeneic Cell Transplantation Using Droplet Digital PCR
por: Lombard, Catherine A., et al.
Publicado: (2019)

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
por: Boon, Ruben, et al.
Publicado: (2020)

The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation
por: Caruso, Marino, et al.
Publicado: (2022)

A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell
por: Wang, Xiaohang, et al.
Publicado: (2018)

Genome-wide next-generation DNA and RNA sequencing reveals a mutation that perturbs splicing of the phosphatidylinositol glycan anchor biosynthesis class H gene (PIGH) and causes arthrogryposis in Belgian Blue cattle
por: Sartelet, Arnaud, et al.
Publicado: (2015)

Isolation, Characterization, and Antibacterial Activity of Hard-to-Culture Actinobacteria from Cave Moonmilk Deposits
por: Adam, Delphine, et al.
Publicado: (2018)

Connecting Mitochondria, Metabolism, and Stem Cell Fate
por: Wanet, Anaïs, et al.
Publicado: (2015)

Human Hepatocytes and Differentiated Adult-Derived Human Liver Stem/Progenitor Cells Display In Vitro Immunosuppressive Properties Mediated, at Least in Part, through the Nonclassical HLA Class I Molecule HLA-G
por: Lombard, Catherine A., et al.
Publicado: (2019)

Stellate cells are mesenchymal stem cells
por: Kordes, Claus, et al.
Publicado: (2014)

Shedding light on stellate cells
por: Alexander, Andrew S, et al.
Publicado: (2018)

Stellate cells in health and disease
por: Vaiphei, Kim
Publicado: (2017)

Hepatic Stellate Cells and Hepatocarcinogenesis
por: Barry, Anna E., et al.
Publicado: (2020)

H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro
por: Vanhove, Jolien, et al.
Publicado: (2016)

Intercellular Adhesive Structures Between Stellate Cells – An Analysis in Cultured Human Hepatic Stellate Cells
por: Imai, Katsuyuki, et al.
Publicado: (2004)

Clinical Protocol to Prevent Thrombogenic Effect of Liver-Derived Mesenchymal Cells for Cell-Based Therapies
por: Coppin, Louise, et al.
Publicado: (2019)

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells
por: Lachowski, Dariusz, et al.
Publicado: (2017)

Benchmarking phasing software with a whole-genome sequenced cattle pedigree
por: Oget-Ebrad, Claire, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9ugq0npqmi11ctbbeeopcndrrp