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Genetics and therapy for pediatric eye diseases

Ocular morphogenesis in vertebrates is a highly organized process, orchestrated largely by intrinsic genetic programs that exhibit stringent spatiotemporal control. Alternations in these genetic instructions can lead to hereditary or nonhereditary congenital disorders, a major cause of childhood vis...

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Detalles Bibliográficos
Autores principales: Chen, Holly.Y., Lehmann, Ordan J., Swaroop, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122153/
https://www.ncbi.nlm.nih.gov/pubmed/33975254
http://dx.doi.org/10.1016/j.ebiom.2021.103360
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author Chen, Holly.Y.
Lehmann, Ordan J.
Swaroop, Anand
author_facet Chen, Holly.Y.
Lehmann, Ordan J.
Swaroop, Anand
author_sort Chen, Holly.Y.
collection PubMed
description Ocular morphogenesis in vertebrates is a highly organized process, orchestrated largely by intrinsic genetic programs that exhibit stringent spatiotemporal control. Alternations in these genetic instructions can lead to hereditary or nonhereditary congenital disorders, a major cause of childhood visual impairment, and contribute to common late-onset blinding diseases. Currently, limited treatment options exist for clinical phenotypes involving eye development. This review summarizes recent advances in our understanding of early-onset ocular disorders and highlights genetic complexities in development and diseases, specifically focusing on coloboma, congenital glaucoma and Leber congenital amaurosis. We also discuss innovative paradigms for potential therapeutic modalities.
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spelling pubmed-81221532021-05-21 Genetics and therapy for pediatric eye diseases Chen, Holly.Y. Lehmann, Ordan J. Swaroop, Anand EBioMedicine Review Ocular morphogenesis in vertebrates is a highly organized process, orchestrated largely by intrinsic genetic programs that exhibit stringent spatiotemporal control. Alternations in these genetic instructions can lead to hereditary or nonhereditary congenital disorders, a major cause of childhood visual impairment, and contribute to common late-onset blinding diseases. Currently, limited treatment options exist for clinical phenotypes involving eye development. This review summarizes recent advances in our understanding of early-onset ocular disorders and highlights genetic complexities in development and diseases, specifically focusing on coloboma, congenital glaucoma and Leber congenital amaurosis. We also discuss innovative paradigms for potential therapeutic modalities. Elsevier 2021-05-08 /pmc/articles/PMC8122153/ /pubmed/33975254 http://dx.doi.org/10.1016/j.ebiom.2021.103360 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Holly.Y.
Lehmann, Ordan J.
Swaroop, Anand
Genetics and therapy for pediatric eye diseases
title Genetics and therapy for pediatric eye diseases
title_full Genetics and therapy for pediatric eye diseases
title_fullStr Genetics and therapy for pediatric eye diseases
title_full_unstemmed Genetics and therapy for pediatric eye diseases
title_short Genetics and therapy for pediatric eye diseases
title_sort genetics and therapy for pediatric eye diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122153/
https://www.ncbi.nlm.nih.gov/pubmed/33975254
http://dx.doi.org/10.1016/j.ebiom.2021.103360
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