Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia

Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may...

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Autores principales: Ott, Ashley, Venkataraman, Vinayak, Badran, Yousef R., Goldman, Rose, Spasic, Smiljana, Vyas, Darshali A., Amrein, Philip, McAfee, Steven, Brunner, Andrew, Fathi, Amir T., Narayan, Rupa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122218/
https://www.ncbi.nlm.nih.gov/pubmed/34026155
http://dx.doi.org/10.1002/ccr3.4115
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author Ott, Ashley
Venkataraman, Vinayak
Badran, Yousef R.
Goldman, Rose
Spasic, Smiljana
Vyas, Darshali A.
Amrein, Philip
McAfee, Steven
Brunner, Andrew
Fathi, Amir T.
Narayan, Rupa
author_facet Ott, Ashley
Venkataraman, Vinayak
Badran, Yousef R.
Goldman, Rose
Spasic, Smiljana
Vyas, Darshali A.
Amrein, Philip
McAfee, Steven
Brunner, Andrew
Fathi, Amir T.
Narayan, Rupa
author_sort Ott, Ashley
collection PubMed
description Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may help guide dose modifications.
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spelling pubmed-81222182021-05-21 Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia Ott, Ashley Venkataraman, Vinayak Badran, Yousef R. Goldman, Rose Spasic, Smiljana Vyas, Darshali A. Amrein, Philip McAfee, Steven Brunner, Andrew Fathi, Amir T. Narayan, Rupa Clin Case Rep Case Reports Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may help guide dose modifications. John Wiley and Sons Inc. 2021-05-15 /pmc/articles/PMC8122218/ /pubmed/34026155 http://dx.doi.org/10.1002/ccr3.4115 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Ott, Ashley
Venkataraman, Vinayak
Badran, Yousef R.
Goldman, Rose
Spasic, Smiljana
Vyas, Darshali A.
Amrein, Philip
McAfee, Steven
Brunner, Andrew
Fathi, Amir T.
Narayan, Rupa
Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
title Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
title_full Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
title_fullStr Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
title_full_unstemmed Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
title_short Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
title_sort arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122218/
https://www.ncbi.nlm.nih.gov/pubmed/34026155
http://dx.doi.org/10.1002/ccr3.4115
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