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Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque

Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief r...

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Autores principales: Kowara, Michal, Cudnoch-Jedrzejewska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122261/
https://www.ncbi.nlm.nih.gov/pubmed/33919446
http://dx.doi.org/10.3390/ijms22094354
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author Kowara, Michal
Cudnoch-Jedrzejewska, Agnieszka
author_facet Kowara, Michal
Cudnoch-Jedrzejewska, Agnieszka
author_sort Kowara, Michal
collection PubMed
description Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief review, the idea of atherosclerotic plaque stabilization and five main approaches—towards the regulation of metabolism, macrophages and cellular death, inflammation, reactive oxygen species, and extracellular matrix remodeling have been presented. Moreover, apart from classical approaches (targeted at the general mechanisms of plaque destabilization), there are also alternative approaches targeted either at certain plaques which have just become vulnerable or targeted at the minimization of the consequences of atherosclerotic plaque erosion or rupture. These alternative approaches have also been briefly mentioned in this review.
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spelling pubmed-81222612021-05-16 Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque Kowara, Michal Cudnoch-Jedrzejewska, Agnieszka Int J Mol Sci Review Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief review, the idea of atherosclerotic plaque stabilization and five main approaches—towards the regulation of metabolism, macrophages and cellular death, inflammation, reactive oxygen species, and extracellular matrix remodeling have been presented. Moreover, apart from classical approaches (targeted at the general mechanisms of plaque destabilization), there are also alternative approaches targeted either at certain plaques which have just become vulnerable or targeted at the minimization of the consequences of atherosclerotic plaque erosion or rupture. These alternative approaches have also been briefly mentioned in this review. MDPI 2021-04-21 /pmc/articles/PMC8122261/ /pubmed/33919446 http://dx.doi.org/10.3390/ijms22094354 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kowara, Michal
Cudnoch-Jedrzejewska, Agnieszka
Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque
title Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque
title_full Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque
title_fullStr Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque
title_full_unstemmed Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque
title_short Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque
title_sort different approaches in therapy aiming to stabilize an unstable atherosclerotic plaque
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122261/
https://www.ncbi.nlm.nih.gov/pubmed/33919446
http://dx.doi.org/10.3390/ijms22094354
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