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Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action

As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chro...

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Detalles Bibliográficos
Autores principales: Ożarowski, Marcin, Karpiński, Tomasz M., Zielińska, Aleksandra, Souto, Eliana B., Wielgus, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122338/
https://www.ncbi.nlm.nih.gov/pubmed/33919010
http://dx.doi.org/10.3390/ijms22094294
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author Ożarowski, Marcin
Karpiński, Tomasz M.
Zielińska, Aleksandra
Souto, Eliana B.
Wielgus, Karolina
author_facet Ożarowski, Marcin
Karpiński, Tomasz M.
Zielińska, Aleksandra
Souto, Eliana B.
Wielgus, Karolina
author_sort Ożarowski, Marcin
collection PubMed
description As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer’s disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach.
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spelling pubmed-81223382021-05-16 Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action Ożarowski, Marcin Karpiński, Tomasz M. Zielińska, Aleksandra Souto, Eliana B. Wielgus, Karolina Int J Mol Sci Review As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer’s disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach. MDPI 2021-04-21 /pmc/articles/PMC8122338/ /pubmed/33919010 http://dx.doi.org/10.3390/ijms22094294 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ożarowski, Marcin
Karpiński, Tomasz M.
Zielińska, Aleksandra
Souto, Eliana B.
Wielgus, Karolina
Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
title Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
title_full Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
title_fullStr Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
title_full_unstemmed Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
title_short Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
title_sort cannabidiol in neurological and neoplastic diseases: latest developments on the molecular mechanism of action
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122338/
https://www.ncbi.nlm.nih.gov/pubmed/33919010
http://dx.doi.org/10.3390/ijms22094294
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