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Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122338/ https://www.ncbi.nlm.nih.gov/pubmed/33919010 http://dx.doi.org/10.3390/ijms22094294 |
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author | Ożarowski, Marcin Karpiński, Tomasz M. Zielińska, Aleksandra Souto, Eliana B. Wielgus, Karolina |
author_facet | Ożarowski, Marcin Karpiński, Tomasz M. Zielińska, Aleksandra Souto, Eliana B. Wielgus, Karolina |
author_sort | Ożarowski, Marcin |
collection | PubMed |
description | As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer’s disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach. |
format | Online Article Text |
id | pubmed-8122338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81223382021-05-16 Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action Ożarowski, Marcin Karpiński, Tomasz M. Zielińska, Aleksandra Souto, Eliana B. Wielgus, Karolina Int J Mol Sci Review As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer’s disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach. MDPI 2021-04-21 /pmc/articles/PMC8122338/ /pubmed/33919010 http://dx.doi.org/10.3390/ijms22094294 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ożarowski, Marcin Karpiński, Tomasz M. Zielińska, Aleksandra Souto, Eliana B. Wielgus, Karolina Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action |
title | Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action |
title_full | Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action |
title_fullStr | Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action |
title_full_unstemmed | Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action |
title_short | Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action |
title_sort | cannabidiol in neurological and neoplastic diseases: latest developments on the molecular mechanism of action |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122338/ https://www.ncbi.nlm.nih.gov/pubmed/33919010 http://dx.doi.org/10.3390/ijms22094294 |
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