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Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool

Numerous studies are continuously being carried out in pursuit of formulations with higher performance. Problems such as poor drug solubility, which hinders drug incorporation into delivery systems and bioavailability, or limitations concerning the stability and performance of the formulations may c...

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Autores principales: Caparica, Rita, Júlio, Ana, Fernandes, Filipe, Araújo, Maria Eduarda M., Costa, João Guilherme, Santos de Almeida, Tânia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122351/
https://www.ncbi.nlm.nih.gov/pubmed/33919354
http://dx.doi.org/10.3390/ijms22094338
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author Caparica, Rita
Júlio, Ana
Fernandes, Filipe
Araújo, Maria Eduarda M.
Costa, João Guilherme
Santos de Almeida, Tânia
author_facet Caparica, Rita
Júlio, Ana
Fernandes, Filipe
Araújo, Maria Eduarda M.
Costa, João Guilherme
Santos de Almeida, Tânia
author_sort Caparica, Rita
collection PubMed
description Numerous studies are continuously being carried out in pursuit of formulations with higher performance. Problems such as poor drug solubility, which hinders drug incorporation into delivery systems and bioavailability, or limitations concerning the stability and performance of the formulations may cause difficulties, since solving all these drawbacks at once is a huge challenge. Ionic liquids (ILs), due to their tunable nature, may hypothetically be synthesized for a particular application. Therefore, predicting the impact of a particular combination of ions within an IL in drug delivery could be a useful strategy. Eight ILs, two choline amino acid ILs, two imidazole halogenated ILs, and four imidazole amino acid ILs, were prepared. Their applicability at non-toxic concentrations, for improving solubility and the incorporation of the poorly soluble, ferulic, caffeic, and p-coumaric acids, as well as rutin, into topical emulsions, was assessed. Next, the impact of the ILs on the performance of the formulations was investigated. Our study showed that choosing the appropriate IL leads to a clear upgrade of a topical emulsion, by optimizing multiple features of its performance, such as improving the delivery of poorly soluble drugs, altering the viscosity, which may lead to better sensorial features, and increasing the stability over time.
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spelling pubmed-81223512021-05-16 Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool Caparica, Rita Júlio, Ana Fernandes, Filipe Araújo, Maria Eduarda M. Costa, João Guilherme Santos de Almeida, Tânia Int J Mol Sci Article Numerous studies are continuously being carried out in pursuit of formulations with higher performance. Problems such as poor drug solubility, which hinders drug incorporation into delivery systems and bioavailability, or limitations concerning the stability and performance of the formulations may cause difficulties, since solving all these drawbacks at once is a huge challenge. Ionic liquids (ILs), due to their tunable nature, may hypothetically be synthesized for a particular application. Therefore, predicting the impact of a particular combination of ions within an IL in drug delivery could be a useful strategy. Eight ILs, two choline amino acid ILs, two imidazole halogenated ILs, and four imidazole amino acid ILs, were prepared. Their applicability at non-toxic concentrations, for improving solubility and the incorporation of the poorly soluble, ferulic, caffeic, and p-coumaric acids, as well as rutin, into topical emulsions, was assessed. Next, the impact of the ILs on the performance of the formulations was investigated. Our study showed that choosing the appropriate IL leads to a clear upgrade of a topical emulsion, by optimizing multiple features of its performance, such as improving the delivery of poorly soluble drugs, altering the viscosity, which may lead to better sensorial features, and increasing the stability over time. MDPI 2021-04-21 /pmc/articles/PMC8122351/ /pubmed/33919354 http://dx.doi.org/10.3390/ijms22094338 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Caparica, Rita
Júlio, Ana
Fernandes, Filipe
Araújo, Maria Eduarda M.
Costa, João Guilherme
Santos de Almeida, Tânia
Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool
title Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool
title_full Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool
title_fullStr Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool
title_full_unstemmed Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool
title_short Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool
title_sort upgrading the topical delivery of poorly soluble drugs using ionic liquids as a versatile tool
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122351/
https://www.ncbi.nlm.nih.gov/pubmed/33919354
http://dx.doi.org/10.3390/ijms22094338
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