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Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications

Fibrinolysis is a crucial physiological process that helps to maintain a hemostatic balance by counteracting excessive thrombosis. The components of the fibrinolytic system are well established and are associated with a wide array of physiological and pathophysiological processes. The aberrant expre...

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Autores principales: Mahmood, Niaz, Rabbani, Shafaat A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122389/
https://www.ncbi.nlm.nih.gov/pubmed/33921923
http://dx.doi.org/10.3390/ijms22094358
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author Mahmood, Niaz
Rabbani, Shafaat A.
author_facet Mahmood, Niaz
Rabbani, Shafaat A.
author_sort Mahmood, Niaz
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description Fibrinolysis is a crucial physiological process that helps to maintain a hemostatic balance by counteracting excessive thrombosis. The components of the fibrinolytic system are well established and are associated with a wide array of physiological and pathophysiological processes. The aberrant expression of several components, especially urokinase-type plasminogen activator (uPA), its cognate receptor uPAR, and plasminogen activator inhibitor-1 (PAI-1), has shown a direct correlation with increased tumor growth, invasiveness, and metastasis. As a result, targeting the fibrinolytic system has been of great interest in the field of cancer biology. Even though there is a plethora of encouraging preclinical evidence on the potential therapeutic benefits of targeting the key oncogenic components of the fibrinolytic system, none of them made it from “bench to bedside” due to a limited number of clinical trials on them. This review summarizes our existing understanding of the various diagnostic and therapeutic strategies targeting the fibrinolytic system during cancer.
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spelling pubmed-81223892021-05-16 Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications Mahmood, Niaz Rabbani, Shafaat A. Int J Mol Sci Review Fibrinolysis is a crucial physiological process that helps to maintain a hemostatic balance by counteracting excessive thrombosis. The components of the fibrinolytic system are well established and are associated with a wide array of physiological and pathophysiological processes. The aberrant expression of several components, especially urokinase-type plasminogen activator (uPA), its cognate receptor uPAR, and plasminogen activator inhibitor-1 (PAI-1), has shown a direct correlation with increased tumor growth, invasiveness, and metastasis. As a result, targeting the fibrinolytic system has been of great interest in the field of cancer biology. Even though there is a plethora of encouraging preclinical evidence on the potential therapeutic benefits of targeting the key oncogenic components of the fibrinolytic system, none of them made it from “bench to bedside” due to a limited number of clinical trials on them. This review summarizes our existing understanding of the various diagnostic and therapeutic strategies targeting the fibrinolytic system during cancer. MDPI 2021-04-22 /pmc/articles/PMC8122389/ /pubmed/33921923 http://dx.doi.org/10.3390/ijms22094358 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mahmood, Niaz
Rabbani, Shafaat A.
Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
title Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
title_full Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
title_fullStr Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
title_full_unstemmed Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
title_short Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
title_sort fibrinolytic system and cancer: diagnostic and therapeutic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122389/
https://www.ncbi.nlm.nih.gov/pubmed/33921923
http://dx.doi.org/10.3390/ijms22094358
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