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Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review

Based on the abundance of scientific publications, the polymodal sensor TRPV1 is known as one of the most studied proteins within the TRP channel family. This receptor has been found in numerous cell types from different species as well as in spermatozoa. The present review is focused on analyzing t...

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Autores principales: Ramal-Sanchez, Marina, Bernabò, Nicola, Valbonetti, Luca, Cimini, Costanza, Taraschi, Angela, Capacchietti, Giulia, Machado-Simoes, Juliana, Barboni, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122410/
https://www.ncbi.nlm.nih.gov/pubmed/33919147
http://dx.doi.org/10.3390/ijms22094306
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author Ramal-Sanchez, Marina
Bernabò, Nicola
Valbonetti, Luca
Cimini, Costanza
Taraschi, Angela
Capacchietti, Giulia
Machado-Simoes, Juliana
Barboni, Barbara
author_facet Ramal-Sanchez, Marina
Bernabò, Nicola
Valbonetti, Luca
Cimini, Costanza
Taraschi, Angela
Capacchietti, Giulia
Machado-Simoes, Juliana
Barboni, Barbara
author_sort Ramal-Sanchez, Marina
collection PubMed
description Based on the abundance of scientific publications, the polymodal sensor TRPV1 is known as one of the most studied proteins within the TRP channel family. This receptor has been found in numerous cell types from different species as well as in spermatozoa. The present review is focused on analyzing the role played by this important channel in the post-ejaculatory life of spermatozoa, where it has been described to be involved in events such as capacitation, acrosome reaction, calcium trafficking, sperm migration, and fertilization. By performing an exhaustive bibliographic search, this review gathers, for the first time, all the modulators of the TRPV1 function that, to our knowledge, were described to date in different species and cell types. Moreover, all those modulators with a relationship with the reproductive process, either found in the female tract, seminal plasma, or spermatozoa, are presented here. Since the sperm migration through the female reproductive tract is one of the most intriguing and less understood events of the fertilization process, in the present work, chemotaxis, thermotaxis, and rheotaxis guiding mechanisms and their relationship with TRPV1 receptor are deeply analyzed, hypothesizing its (in)direct participation during the sperm migration. Last, TRPV1 is presented as a pharmacological target, with a special focus on humans and some pathologies in mammals strictly related to the male reproductive system.
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spelling pubmed-81224102021-05-16 Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review Ramal-Sanchez, Marina Bernabò, Nicola Valbonetti, Luca Cimini, Costanza Taraschi, Angela Capacchietti, Giulia Machado-Simoes, Juliana Barboni, Barbara Int J Mol Sci Review Based on the abundance of scientific publications, the polymodal sensor TRPV1 is known as one of the most studied proteins within the TRP channel family. This receptor has been found in numerous cell types from different species as well as in spermatozoa. The present review is focused on analyzing the role played by this important channel in the post-ejaculatory life of spermatozoa, where it has been described to be involved in events such as capacitation, acrosome reaction, calcium trafficking, sperm migration, and fertilization. By performing an exhaustive bibliographic search, this review gathers, for the first time, all the modulators of the TRPV1 function that, to our knowledge, were described to date in different species and cell types. Moreover, all those modulators with a relationship with the reproductive process, either found in the female tract, seminal plasma, or spermatozoa, are presented here. Since the sperm migration through the female reproductive tract is one of the most intriguing and less understood events of the fertilization process, in the present work, chemotaxis, thermotaxis, and rheotaxis guiding mechanisms and their relationship with TRPV1 receptor are deeply analyzed, hypothesizing its (in)direct participation during the sperm migration. Last, TRPV1 is presented as a pharmacological target, with a special focus on humans and some pathologies in mammals strictly related to the male reproductive system. MDPI 2021-04-21 /pmc/articles/PMC8122410/ /pubmed/33919147 http://dx.doi.org/10.3390/ijms22094306 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ramal-Sanchez, Marina
Bernabò, Nicola
Valbonetti, Luca
Cimini, Costanza
Taraschi, Angela
Capacchietti, Giulia
Machado-Simoes, Juliana
Barboni, Barbara
Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review
title Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review
title_full Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review
title_fullStr Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review
title_full_unstemmed Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review
title_short Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review
title_sort role and modulation of trpv1 in mammalian spermatozoa: an updated review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122410/
https://www.ncbi.nlm.nih.gov/pubmed/33919147
http://dx.doi.org/10.3390/ijms22094306
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