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Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122412/ https://www.ncbi.nlm.nih.gov/pubmed/33919088 http://dx.doi.org/10.3390/molecules26092407 |
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author | Bungau, Simona Vesa, Cosmin Mihai Abid, Areha Behl, Tapan Tit, Delia Mirela Purza, Anamaria Lavinia Pasca, Bianca Todan, Laura Maghiar Endres, Laura |
author_facet | Bungau, Simona Vesa, Cosmin Mihai Abid, Areha Behl, Tapan Tit, Delia Mirela Purza, Anamaria Lavinia Pasca, Bianca Todan, Laura Maghiar Endres, Laura |
author_sort | Bungau, Simona |
collection | PubMed |
description | Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies. |
format | Online Article Text |
id | pubmed-8122412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81224122021-05-16 Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases Bungau, Simona Vesa, Cosmin Mihai Abid, Areha Behl, Tapan Tit, Delia Mirela Purza, Anamaria Lavinia Pasca, Bianca Todan, Laura Maghiar Endres, Laura Molecules Review Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies. MDPI 2021-04-21 /pmc/articles/PMC8122412/ /pubmed/33919088 http://dx.doi.org/10.3390/molecules26092407 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bungau, Simona Vesa, Cosmin Mihai Abid, Areha Behl, Tapan Tit, Delia Mirela Purza, Anamaria Lavinia Pasca, Bianca Todan, Laura Maghiar Endres, Laura Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
title | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
title_full | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
title_fullStr | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
title_full_unstemmed | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
title_short | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
title_sort | withaferin a—a promising phytochemical compound with multiple results in dermatological diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122412/ https://www.ncbi.nlm.nih.gov/pubmed/33919088 http://dx.doi.org/10.3390/molecules26092407 |
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