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Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases

Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in...

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Autores principales: Bungau, Simona, Vesa, Cosmin Mihai, Abid, Areha, Behl, Tapan, Tit, Delia Mirela, Purza, Anamaria Lavinia, Pasca, Bianca, Todan, Laura Maghiar, Endres, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122412/
https://www.ncbi.nlm.nih.gov/pubmed/33919088
http://dx.doi.org/10.3390/molecules26092407
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author Bungau, Simona
Vesa, Cosmin Mihai
Abid, Areha
Behl, Tapan
Tit, Delia Mirela
Purza, Anamaria Lavinia
Pasca, Bianca
Todan, Laura Maghiar
Endres, Laura
author_facet Bungau, Simona
Vesa, Cosmin Mihai
Abid, Areha
Behl, Tapan
Tit, Delia Mirela
Purza, Anamaria Lavinia
Pasca, Bianca
Todan, Laura Maghiar
Endres, Laura
author_sort Bungau, Simona
collection PubMed
description Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies.
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spelling pubmed-81224122021-05-16 Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases Bungau, Simona Vesa, Cosmin Mihai Abid, Areha Behl, Tapan Tit, Delia Mirela Purza, Anamaria Lavinia Pasca, Bianca Todan, Laura Maghiar Endres, Laura Molecules Review Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies. MDPI 2021-04-21 /pmc/articles/PMC8122412/ /pubmed/33919088 http://dx.doi.org/10.3390/molecules26092407 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bungau, Simona
Vesa, Cosmin Mihai
Abid, Areha
Behl, Tapan
Tit, Delia Mirela
Purza, Anamaria Lavinia
Pasca, Bianca
Todan, Laura Maghiar
Endres, Laura
Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
title Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
title_full Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
title_fullStr Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
title_full_unstemmed Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
title_short Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
title_sort withaferin a—a promising phytochemical compound with multiple results in dermatological diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122412/
https://www.ncbi.nlm.nih.gov/pubmed/33919088
http://dx.doi.org/10.3390/molecules26092407
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