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A Phase 2 Clinical Trial of Trametinib and Low-Dose Dabrafenib in Patients with Advanced Pretreated NRAS(Q61R/K/L) Mutant Melanoma (TraMel-WT)

SIMPLE SUMMARY: MEK-inhibitor monotherapy has activity in advanced NRAS(Q61R/K/L) mutant melanoma but is associated with dose-limiting cutaneous toxicity. The combination of a BRAF- with a MEK-inhibitor at their full dose (as in BRAF(V600E/K) mutant melanoma) has low cutaneous toxicity. We hypothesi...

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Detalles Bibliográficos
Autores principales:	Awada, Gil, Schwarze, Julia Katharina, Tijtgat, Jens, Fasolino, Giuseppe, Everaert, Hendrik, Neyns, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122428/ https://www.ncbi.nlm.nih.gov/pubmed/33921947 http://dx.doi.org/10.3390/cancers13092010

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