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Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy

SIMPLE SUMMARY: Diagnostic approaches and chemotherapeutic delivery based on nanotechnologies, such as nanoparticles (NPs), could be promising candidates for the new era of cancer research. Recently great attention has been received by carbon-based nanomaterials such as Carbon Dots (CDs), due their...

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Autores principales: Nocito, Giuseppe, Calabrese, Giovanna, Forte, Stefano, Petralia, Salvatore, Puglisi, Caterina, Campolo, Michela, Esposito, Emanuela, Conoci, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122497/
https://www.ncbi.nlm.nih.gov/pubmed/33919096
http://dx.doi.org/10.3390/cancers13091991
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author Nocito, Giuseppe
Calabrese, Giovanna
Forte, Stefano
Petralia, Salvatore
Puglisi, Caterina
Campolo, Michela
Esposito, Emanuela
Conoci, Sabrina
author_facet Nocito, Giuseppe
Calabrese, Giovanna
Forte, Stefano
Petralia, Salvatore
Puglisi, Caterina
Campolo, Michela
Esposito, Emanuela
Conoci, Sabrina
author_sort Nocito, Giuseppe
collection PubMed
description SIMPLE SUMMARY: Diagnostic approaches and chemotherapeutic delivery based on nanotechnologies, such as nanoparticles (NPs), could be promising candidates for the new era of cancer research. Recently great attention has been received by carbon-based nanomaterials such as Carbon Dots (CDs), due their variegated physical-chemical properties that makes these systems appealing for multiple use from bioimaging, biosensing, nano-carriers for drug delivery systems to innovative therapeutic agents in photodynamic (PDT) and photothermal therapy (PTT). In this review, we report the last evidence on the application and prospects of CDs as useful nano theranostics tools for cancer diagnosis and therapy. ABSTRACT: Carbon Dots (CDs) are the latest members of carbon-based nanomaterials, which since their discovery have attracted notable attention due to their chemical and mechanical properties, brilliant fluorescence, high photostability, and good biocompatibility. Together with the ease and affordable preparation costs, these intrinsic features make CDs the most promising nanomaterials for multiple applications in the biological field, such as bioimaging, biotherapy, and gene/drug delivery. This review will illustrate the most recent applications of CDs in the biomedical field, focusing on their biocompatibility, fluorescence, low cytotoxicity, cellular uptake, and theranostic properties to highlight above all their usefulness as a promising tool for cancer diagnosis and therapy.
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spelling pubmed-81224972021-05-16 Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy Nocito, Giuseppe Calabrese, Giovanna Forte, Stefano Petralia, Salvatore Puglisi, Caterina Campolo, Michela Esposito, Emanuela Conoci, Sabrina Cancers (Basel) Review SIMPLE SUMMARY: Diagnostic approaches and chemotherapeutic delivery based on nanotechnologies, such as nanoparticles (NPs), could be promising candidates for the new era of cancer research. Recently great attention has been received by carbon-based nanomaterials such as Carbon Dots (CDs), due their variegated physical-chemical properties that makes these systems appealing for multiple use from bioimaging, biosensing, nano-carriers for drug delivery systems to innovative therapeutic agents in photodynamic (PDT) and photothermal therapy (PTT). In this review, we report the last evidence on the application and prospects of CDs as useful nano theranostics tools for cancer diagnosis and therapy. ABSTRACT: Carbon Dots (CDs) are the latest members of carbon-based nanomaterials, which since their discovery have attracted notable attention due to their chemical and mechanical properties, brilliant fluorescence, high photostability, and good biocompatibility. Together with the ease and affordable preparation costs, these intrinsic features make CDs the most promising nanomaterials for multiple applications in the biological field, such as bioimaging, biotherapy, and gene/drug delivery. This review will illustrate the most recent applications of CDs in the biomedical field, focusing on their biocompatibility, fluorescence, low cytotoxicity, cellular uptake, and theranostic properties to highlight above all their usefulness as a promising tool for cancer diagnosis and therapy. MDPI 2021-04-21 /pmc/articles/PMC8122497/ /pubmed/33919096 http://dx.doi.org/10.3390/cancers13091991 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nocito, Giuseppe
Calabrese, Giovanna
Forte, Stefano
Petralia, Salvatore
Puglisi, Caterina
Campolo, Michela
Esposito, Emanuela
Conoci, Sabrina
Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy
title Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy
title_full Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy
title_fullStr Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy
title_full_unstemmed Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy
title_short Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy
title_sort carbon dots as promising tools for cancer diagnosis and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122497/
https://www.ncbi.nlm.nih.gov/pubmed/33919096
http://dx.doi.org/10.3390/cancers13091991
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