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Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy
SIMPLE SUMMARY: Diagnostic approaches and chemotherapeutic delivery based on nanotechnologies, such as nanoparticles (NPs), could be promising candidates for the new era of cancer research. Recently great attention has been received by carbon-based nanomaterials such as Carbon Dots (CDs), due their...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122497/ https://www.ncbi.nlm.nih.gov/pubmed/33919096 http://dx.doi.org/10.3390/cancers13091991 |
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author | Nocito, Giuseppe Calabrese, Giovanna Forte, Stefano Petralia, Salvatore Puglisi, Caterina Campolo, Michela Esposito, Emanuela Conoci, Sabrina |
author_facet | Nocito, Giuseppe Calabrese, Giovanna Forte, Stefano Petralia, Salvatore Puglisi, Caterina Campolo, Michela Esposito, Emanuela Conoci, Sabrina |
author_sort | Nocito, Giuseppe |
collection | PubMed |
description | SIMPLE SUMMARY: Diagnostic approaches and chemotherapeutic delivery based on nanotechnologies, such as nanoparticles (NPs), could be promising candidates for the new era of cancer research. Recently great attention has been received by carbon-based nanomaterials such as Carbon Dots (CDs), due their variegated physical-chemical properties that makes these systems appealing for multiple use from bioimaging, biosensing, nano-carriers for drug delivery systems to innovative therapeutic agents in photodynamic (PDT) and photothermal therapy (PTT). In this review, we report the last evidence on the application and prospects of CDs as useful nano theranostics tools for cancer diagnosis and therapy. ABSTRACT: Carbon Dots (CDs) are the latest members of carbon-based nanomaterials, which since their discovery have attracted notable attention due to their chemical and mechanical properties, brilliant fluorescence, high photostability, and good biocompatibility. Together with the ease and affordable preparation costs, these intrinsic features make CDs the most promising nanomaterials for multiple applications in the biological field, such as bioimaging, biotherapy, and gene/drug delivery. This review will illustrate the most recent applications of CDs in the biomedical field, focusing on their biocompatibility, fluorescence, low cytotoxicity, cellular uptake, and theranostic properties to highlight above all their usefulness as a promising tool for cancer diagnosis and therapy. |
format | Online Article Text |
id | pubmed-8122497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81224972021-05-16 Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy Nocito, Giuseppe Calabrese, Giovanna Forte, Stefano Petralia, Salvatore Puglisi, Caterina Campolo, Michela Esposito, Emanuela Conoci, Sabrina Cancers (Basel) Review SIMPLE SUMMARY: Diagnostic approaches and chemotherapeutic delivery based on nanotechnologies, such as nanoparticles (NPs), could be promising candidates for the new era of cancer research. Recently great attention has been received by carbon-based nanomaterials such as Carbon Dots (CDs), due their variegated physical-chemical properties that makes these systems appealing for multiple use from bioimaging, biosensing, nano-carriers for drug delivery systems to innovative therapeutic agents in photodynamic (PDT) and photothermal therapy (PTT). In this review, we report the last evidence on the application and prospects of CDs as useful nano theranostics tools for cancer diagnosis and therapy. ABSTRACT: Carbon Dots (CDs) are the latest members of carbon-based nanomaterials, which since their discovery have attracted notable attention due to their chemical and mechanical properties, brilliant fluorescence, high photostability, and good biocompatibility. Together with the ease and affordable preparation costs, these intrinsic features make CDs the most promising nanomaterials for multiple applications in the biological field, such as bioimaging, biotherapy, and gene/drug delivery. This review will illustrate the most recent applications of CDs in the biomedical field, focusing on their biocompatibility, fluorescence, low cytotoxicity, cellular uptake, and theranostic properties to highlight above all their usefulness as a promising tool for cancer diagnosis and therapy. MDPI 2021-04-21 /pmc/articles/PMC8122497/ /pubmed/33919096 http://dx.doi.org/10.3390/cancers13091991 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nocito, Giuseppe Calabrese, Giovanna Forte, Stefano Petralia, Salvatore Puglisi, Caterina Campolo, Michela Esposito, Emanuela Conoci, Sabrina Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy |
title | Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy |
title_full | Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy |
title_fullStr | Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy |
title_full_unstemmed | Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy |
title_short | Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy |
title_sort | carbon dots as promising tools for cancer diagnosis and therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122497/ https://www.ncbi.nlm.nih.gov/pubmed/33919096 http://dx.doi.org/10.3390/cancers13091991 |
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