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Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process

Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and finally culminating with the formation of a fibrin clot. However, delay in the normal wound healing process during pathological conditions due to reactive oxygen species, inflammation and im...

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Autores principales: Süntar, Ipek, Çetinkaya, Sümeyra, Panieri, Emiliano, Saha, Sarmistha, Buttari, Brigitta, Profumo, Elisabetta, Saso, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122529/
https://www.ncbi.nlm.nih.gov/pubmed/33919399
http://dx.doi.org/10.3390/molecules26092424
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author Süntar, Ipek
Çetinkaya, Sümeyra
Panieri, Emiliano
Saha, Sarmistha
Buttari, Brigitta
Profumo, Elisabetta
Saso, Luciano
author_facet Süntar, Ipek
Çetinkaya, Sümeyra
Panieri, Emiliano
Saha, Sarmistha
Buttari, Brigitta
Profumo, Elisabetta
Saso, Luciano
author_sort Süntar, Ipek
collection PubMed
description Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and finally culminating with the formation of a fibrin clot. However, delay in the normal wound healing process during pathological conditions due to reactive oxygen species, inflammation and immune suppression at the wound site represents a medical challenge. So far, many therapeutic strategies have been developed to improve cellular homeostasis and chronic wounds in order to accelerate wound repair. In this context, the role of Nuclear factor erythroid 2-related factor 2 (Nrf2) during the wound healing process has been a stimulating research topic for therapeutic perspectives. Nrf2 is the main regulator of intracellular redox homeostasis. It increases cytoprotective gene expression and the antioxidant capacity of mammalian cells. It has been reported that some bioactive compounds attenuate cellular stress and thus accelerate cell proliferation, neovascularization and repair of damaged tissues by promoting Nrf2 activation. This review highlights the importance of the Nrf2 signaling pathway in wound healing strategies and the role of bioactive compounds that support wound repair through the modulation of this crucial transcription factor.
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spelling pubmed-81225292021-05-16 Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process Süntar, Ipek Çetinkaya, Sümeyra Panieri, Emiliano Saha, Sarmistha Buttari, Brigitta Profumo, Elisabetta Saso, Luciano Molecules Review Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and finally culminating with the formation of a fibrin clot. However, delay in the normal wound healing process during pathological conditions due to reactive oxygen species, inflammation and immune suppression at the wound site represents a medical challenge. So far, many therapeutic strategies have been developed to improve cellular homeostasis and chronic wounds in order to accelerate wound repair. In this context, the role of Nuclear factor erythroid 2-related factor 2 (Nrf2) during the wound healing process has been a stimulating research topic for therapeutic perspectives. Nrf2 is the main regulator of intracellular redox homeostasis. It increases cytoprotective gene expression and the antioxidant capacity of mammalian cells. It has been reported that some bioactive compounds attenuate cellular stress and thus accelerate cell proliferation, neovascularization and repair of damaged tissues by promoting Nrf2 activation. This review highlights the importance of the Nrf2 signaling pathway in wound healing strategies and the role of bioactive compounds that support wound repair through the modulation of this crucial transcription factor. MDPI 2021-04-21 /pmc/articles/PMC8122529/ /pubmed/33919399 http://dx.doi.org/10.3390/molecules26092424 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Süntar, Ipek
Çetinkaya, Sümeyra
Panieri, Emiliano
Saha, Sarmistha
Buttari, Brigitta
Profumo, Elisabetta
Saso, Luciano
Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process
title Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process
title_full Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process
title_fullStr Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process
title_full_unstemmed Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process
title_short Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process
title_sort regulatory role of nrf2 signaling pathway in wound healing process
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122529/
https://www.ncbi.nlm.nih.gov/pubmed/33919399
http://dx.doi.org/10.3390/molecules26092424
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