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A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity

The diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer’s disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as a model to study Parkinson’s disease. To test this idea, 10 adult male O. degu...

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Autores principales: Cuenca-Bermejo, Lorena, Pizzichini, Elisa, Gonçalves, Valeria C., Guillén-Díaz, María, Aguilar-Moñino, Elena, Sánchez-Rodrigo, Consuelo, González-Cuello, Ana-María, Fernández-Villalba, Emiliano, Herrero, María Trinidad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122583/
https://www.ncbi.nlm.nih.gov/pubmed/33919373
http://dx.doi.org/10.3390/ijms22094341
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author Cuenca-Bermejo, Lorena
Pizzichini, Elisa
Gonçalves, Valeria C.
Guillén-Díaz, María
Aguilar-Moñino, Elena
Sánchez-Rodrigo, Consuelo
González-Cuello, Ana-María
Fernández-Villalba, Emiliano
Herrero, María Trinidad
author_facet Cuenca-Bermejo, Lorena
Pizzichini, Elisa
Gonçalves, Valeria C.
Guillén-Díaz, María
Aguilar-Moñino, Elena
Sánchez-Rodrigo, Consuelo
González-Cuello, Ana-María
Fernández-Villalba, Emiliano
Herrero, María Trinidad
author_sort Cuenca-Bermejo, Lorena
collection PubMed
description The diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer’s disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as a model to study Parkinson’s disease. To test this idea, 10 adult male O. degus were divided into control group and MPTP-intoxicated animals. Motor condition and cognition were examined. Dopaminergic degeneration was studied in the ventral mesencephalon and in the striatum. Neuroinflammation was also evaluated in the ventral mesencephalon, in the striatum and in the dorsal hippocampus. MPTP animals showed significant alterations in motor activity and in visuospatial memory. Postmortem analysis revealed a significant decrease in the number of dopaminergic neurons in the ventral mesencephalon of MPTP animals, although no differences were found in their striatal terminals. We observed a significant increase in neuroinflammatory responses in the mesencephalon, in the striatum and in the hippocampus of MPTP-intoxicated animals. Additionally, changes in the subcellular expression of the calcium-binding protein S100β were found in the astrocytes in the nigrostriatal pathway. These findings prove for the first time that O. degus are sensitive to MPTP intoxication and, therefore, is a suitable model for experimental Parkinsonism in the context of aging.
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spelling pubmed-81225832021-05-16 A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity Cuenca-Bermejo, Lorena Pizzichini, Elisa Gonçalves, Valeria C. Guillén-Díaz, María Aguilar-Moñino, Elena Sánchez-Rodrigo, Consuelo González-Cuello, Ana-María Fernández-Villalba, Emiliano Herrero, María Trinidad Int J Mol Sci Article The diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer’s disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as a model to study Parkinson’s disease. To test this idea, 10 adult male O. degus were divided into control group and MPTP-intoxicated animals. Motor condition and cognition were examined. Dopaminergic degeneration was studied in the ventral mesencephalon and in the striatum. Neuroinflammation was also evaluated in the ventral mesencephalon, in the striatum and in the dorsal hippocampus. MPTP animals showed significant alterations in motor activity and in visuospatial memory. Postmortem analysis revealed a significant decrease in the number of dopaminergic neurons in the ventral mesencephalon of MPTP animals, although no differences were found in their striatal terminals. We observed a significant increase in neuroinflammatory responses in the mesencephalon, in the striatum and in the hippocampus of MPTP-intoxicated animals. Additionally, changes in the subcellular expression of the calcium-binding protein S100β were found in the astrocytes in the nigrostriatal pathway. These findings prove for the first time that O. degus are sensitive to MPTP intoxication and, therefore, is a suitable model for experimental Parkinsonism in the context of aging. MDPI 2021-04-21 /pmc/articles/PMC8122583/ /pubmed/33919373 http://dx.doi.org/10.3390/ijms22094341 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cuenca-Bermejo, Lorena
Pizzichini, Elisa
Gonçalves, Valeria C.
Guillén-Díaz, María
Aguilar-Moñino, Elena
Sánchez-Rodrigo, Consuelo
González-Cuello, Ana-María
Fernández-Villalba, Emiliano
Herrero, María Trinidad
A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity
title A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity
title_full A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity
title_fullStr A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity
title_full_unstemmed A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity
title_short A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity
title_sort new tool to study parkinsonism in the context of aging: mptp intoxication in a natural model of multimorbidity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122583/
https://www.ncbi.nlm.nih.gov/pubmed/33919373
http://dx.doi.org/10.3390/ijms22094341
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