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A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity
The diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer’s disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as a model to study Parkinson’s disease. To test this idea, 10 adult male O. degu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122583/ https://www.ncbi.nlm.nih.gov/pubmed/33919373 http://dx.doi.org/10.3390/ijms22094341 |
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author | Cuenca-Bermejo, Lorena Pizzichini, Elisa Gonçalves, Valeria C. Guillén-Díaz, María Aguilar-Moñino, Elena Sánchez-Rodrigo, Consuelo González-Cuello, Ana-María Fernández-Villalba, Emiliano Herrero, María Trinidad |
author_facet | Cuenca-Bermejo, Lorena Pizzichini, Elisa Gonçalves, Valeria C. Guillén-Díaz, María Aguilar-Moñino, Elena Sánchez-Rodrigo, Consuelo González-Cuello, Ana-María Fernández-Villalba, Emiliano Herrero, María Trinidad |
author_sort | Cuenca-Bermejo, Lorena |
collection | PubMed |
description | The diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer’s disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as a model to study Parkinson’s disease. To test this idea, 10 adult male O. degus were divided into control group and MPTP-intoxicated animals. Motor condition and cognition were examined. Dopaminergic degeneration was studied in the ventral mesencephalon and in the striatum. Neuroinflammation was also evaluated in the ventral mesencephalon, in the striatum and in the dorsal hippocampus. MPTP animals showed significant alterations in motor activity and in visuospatial memory. Postmortem analysis revealed a significant decrease in the number of dopaminergic neurons in the ventral mesencephalon of MPTP animals, although no differences were found in their striatal terminals. We observed a significant increase in neuroinflammatory responses in the mesencephalon, in the striatum and in the hippocampus of MPTP-intoxicated animals. Additionally, changes in the subcellular expression of the calcium-binding protein S100β were found in the astrocytes in the nigrostriatal pathway. These findings prove for the first time that O. degus are sensitive to MPTP intoxication and, therefore, is a suitable model for experimental Parkinsonism in the context of aging. |
format | Online Article Text |
id | pubmed-8122583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81225832021-05-16 A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity Cuenca-Bermejo, Lorena Pizzichini, Elisa Gonçalves, Valeria C. Guillén-Díaz, María Aguilar-Moñino, Elena Sánchez-Rodrigo, Consuelo González-Cuello, Ana-María Fernández-Villalba, Emiliano Herrero, María Trinidad Int J Mol Sci Article The diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer’s disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as a model to study Parkinson’s disease. To test this idea, 10 adult male O. degus were divided into control group and MPTP-intoxicated animals. Motor condition and cognition were examined. Dopaminergic degeneration was studied in the ventral mesencephalon and in the striatum. Neuroinflammation was also evaluated in the ventral mesencephalon, in the striatum and in the dorsal hippocampus. MPTP animals showed significant alterations in motor activity and in visuospatial memory. Postmortem analysis revealed a significant decrease in the number of dopaminergic neurons in the ventral mesencephalon of MPTP animals, although no differences were found in their striatal terminals. We observed a significant increase in neuroinflammatory responses in the mesencephalon, in the striatum and in the hippocampus of MPTP-intoxicated animals. Additionally, changes in the subcellular expression of the calcium-binding protein S100β were found in the astrocytes in the nigrostriatal pathway. These findings prove for the first time that O. degus are sensitive to MPTP intoxication and, therefore, is a suitable model for experimental Parkinsonism in the context of aging. MDPI 2021-04-21 /pmc/articles/PMC8122583/ /pubmed/33919373 http://dx.doi.org/10.3390/ijms22094341 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cuenca-Bermejo, Lorena Pizzichini, Elisa Gonçalves, Valeria C. Guillén-Díaz, María Aguilar-Moñino, Elena Sánchez-Rodrigo, Consuelo González-Cuello, Ana-María Fernández-Villalba, Emiliano Herrero, María Trinidad A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity |
title | A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity |
title_full | A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity |
title_fullStr | A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity |
title_full_unstemmed | A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity |
title_short | A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity |
title_sort | new tool to study parkinsonism in the context of aging: mptp intoxication in a natural model of multimorbidity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122583/ https://www.ncbi.nlm.nih.gov/pubmed/33919373 http://dx.doi.org/10.3390/ijms22094341 |
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