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Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS
Chronic pain syndromes are an important medical problem generated by various molecular, genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic pain are the most important pathological processes associated with chronic pain in adults. Standard approaches to the treat...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122598/ https://www.ncbi.nlm.nih.gov/pubmed/33921984 http://dx.doi.org/10.3390/molecules26092431 |
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author | Shnayder, Natalia A. Petrova, Marina M. Popova, Tatiana E. Davidova, Tatiana K. Bobrova, Olga P. Trefilova, Vera V. Goncharova, Polina S. Balberova, Olga V. Petrov, Kirill V. Gavrilyuk, Oksana A. Soloveva, Irina A. Medvedev, German V. Nasyrova, Regina F. |
author_facet | Shnayder, Natalia A. Petrova, Marina M. Popova, Tatiana E. Davidova, Tatiana K. Bobrova, Olga P. Trefilova, Vera V. Goncharova, Polina S. Balberova, Olga V. Petrov, Kirill V. Gavrilyuk, Oksana A. Soloveva, Irina A. Medvedev, German V. Nasyrova, Regina F. |
author_sort | Shnayder, Natalia A. |
collection | PubMed |
description | Chronic pain syndromes are an important medical problem generated by various molecular, genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic pain are the most important pathological processes associated with chronic pain in adults. Standard approaches to the treatment of them do not solve the problem of pain chronicity. This is the reason for the search for new personalized strategies for the prevention and treatment of chronic pain. The nitric oxide (NO) system can play one of the key roles in the development of peripheral pain and its chronicity. The purpose of the study is to review publications devoted to changes in the NO system in patients with peripheral chronical pain syndromes. We have carried out a search for the articles published in e-Library, PubMed, Oxford Press, Clinical Case, Springer, Elsevier, and Google Scholar databases. The search was carried out using keywords and their combinations. The role of NO and NO synthases (NOS) isoforms in peripheral pain development and chronicity was demonstrated primarily from animal models to humans. The most studied is the neuronal NOS (nNOS). The role of inducible NOS (iNOS) and endothelial NOS (eNOS) is still under investigation. Associative genetic studies have shown that single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes encoding nNOS, iNOS, and eNOS may be associated with acute and chronic peripheral pain. Prospects for the use of NOS inhibitors to modulate the effect of drugs used to treat peripheral pain syndrome are discussed. Associative genetic studies of SNVs NOS1, NOS2, and NOS3 genes are important for understanding genetic predictors of peripheral pain chronicity and development of new personalized pharmacotherapy strategies. |
format | Online Article Text |
id | pubmed-8122598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81225982021-05-16 Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS Shnayder, Natalia A. Petrova, Marina M. Popova, Tatiana E. Davidova, Tatiana K. Bobrova, Olga P. Trefilova, Vera V. Goncharova, Polina S. Balberova, Olga V. Petrov, Kirill V. Gavrilyuk, Oksana A. Soloveva, Irina A. Medvedev, German V. Nasyrova, Regina F. Molecules Review Chronic pain syndromes are an important medical problem generated by various molecular, genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic pain are the most important pathological processes associated with chronic pain in adults. Standard approaches to the treatment of them do not solve the problem of pain chronicity. This is the reason for the search for new personalized strategies for the prevention and treatment of chronic pain. The nitric oxide (NO) system can play one of the key roles in the development of peripheral pain and its chronicity. The purpose of the study is to review publications devoted to changes in the NO system in patients with peripheral chronical pain syndromes. We have carried out a search for the articles published in e-Library, PubMed, Oxford Press, Clinical Case, Springer, Elsevier, and Google Scholar databases. The search was carried out using keywords and their combinations. The role of NO and NO synthases (NOS) isoforms in peripheral pain development and chronicity was demonstrated primarily from animal models to humans. The most studied is the neuronal NOS (nNOS). The role of inducible NOS (iNOS) and endothelial NOS (eNOS) is still under investigation. Associative genetic studies have shown that single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes encoding nNOS, iNOS, and eNOS may be associated with acute and chronic peripheral pain. Prospects for the use of NOS inhibitors to modulate the effect of drugs used to treat peripheral pain syndrome are discussed. Associative genetic studies of SNVs NOS1, NOS2, and NOS3 genes are important for understanding genetic predictors of peripheral pain chronicity and development of new personalized pharmacotherapy strategies. MDPI 2021-04-22 /pmc/articles/PMC8122598/ /pubmed/33921984 http://dx.doi.org/10.3390/molecules26092431 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shnayder, Natalia A. Petrova, Marina M. Popova, Tatiana E. Davidova, Tatiana K. Bobrova, Olga P. Trefilova, Vera V. Goncharova, Polina S. Balberova, Olga V. Petrov, Kirill V. Gavrilyuk, Oksana A. Soloveva, Irina A. Medvedev, German V. Nasyrova, Regina F. Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS |
title | Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS |
title_full | Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS |
title_fullStr | Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS |
title_full_unstemmed | Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS |
title_short | Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS |
title_sort | prospects for the personalized multimodal therapy approach to pain management via action on no and nos |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122598/ https://www.ncbi.nlm.nih.gov/pubmed/33921984 http://dx.doi.org/10.3390/molecules26092431 |
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