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A Spectroscopic Overview of Intramolecular Hydrogen Bonds of NH…O,S,N Type

Intramolecular NH…O,S,N interactions in non-tautomeric systems are reviewed in a broad range of compounds covering a variety of NH donors and hydrogen bond acceptors. (1)H chemical shifts of NH donors are good tools to study intramolecular hydrogen bonding. However in some cases they have to be corr...

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Detalles Bibliográficos
Autor principal: Hansen, Poul Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122615/
https://www.ncbi.nlm.nih.gov/pubmed/33919132
http://dx.doi.org/10.3390/molecules26092409
Descripción
Sumario:Intramolecular NH…O,S,N interactions in non-tautomeric systems are reviewed in a broad range of compounds covering a variety of NH donors and hydrogen bond acceptors. (1)H chemical shifts of NH donors are good tools to study intramolecular hydrogen bonding. However in some cases they have to be corrected for ring current effects. Deuterium isotope effects on (13)C and (15)N chemical shifts and primary isotope effects are usually used to judge the strength of hydrogen bonds. Primary isotope effects are investigated in a new range of magnitudes. Isotope ratios of NH stretching frequencies, νNH/ND, are revisited. Hydrogen bond energies are reviewed and two-bond deuterium isotope effects on (13)C chemical shifts are investigated as a possible means of estimating hydrogen bond energies.