4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a Major Active Metabolite of Bisphenol A, Triggers Pancreatic β-Cell Death via a JNK/AMPKα Activation-Regulated Endoplasmic Reticulum Stress-Mediated Apoptotic Pathway

4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), a major active metabolite of bisphenol A (BPA), is generated in the mammalian liver. Some studies have suggested that MBP exerts greater toxicity than BPA. However, the mechanism underlying MBP-induced pancreatic β-cell cytotoxicity remains largely...

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Detalles Bibliográficos
Autores principales: Huang, Cheng-Chin, Yang, Ching-Yao, Su, Chin-Chuan, Fang, Kai-Min, Yen, Cheng-Chieh, Lin, Ching-Ting, Liu, Jui-Min, Lee, Kuan-I, Chen, Ya-Wen, Liu, Shing-Hwa, Huang, Chun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122752/
https://www.ncbi.nlm.nih.gov/pubmed/33922211
http://dx.doi.org/10.3390/ijms22094379

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