Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context

SIMPLE SUMMARY: In virtually all human malignancies, the CDK-RB-E2F pathway is dysregulated resulting in the activation of the E2F transcriptional network. Rb and atypical E2Fs are the most important negative regulators of E2F-dependent transcription during tumorigenesis. However, it is unknown whet...

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Autores principales: Moreno, Eva, Pandit, Shusil K., Toussaint, Mathilda J. M., Bongiovanni, Laura, Harkema, Liesbeth, van Essen, Saskia C., van Liere, Elsbeth A., Westendorp, Bart, de Bruin, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122802/
https://www.ncbi.nlm.nih.gov/pubmed/33922435
http://dx.doi.org/10.3390/cancers13092033

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