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Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations
The wider use of gastrointestinal endoscopic procedures has led to an increased detection of small intestinal preneoplastic and neoplastic epithelial lesions, most of which are identified in the duodenum and ampullary region. Like their malignant counterparts, small intestinal glandular precursor le...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122855/ https://www.ncbi.nlm.nih.gov/pubmed/33922305 http://dx.doi.org/10.3390/ijms22094388 |
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author | Vanoli, Alessandro Grillo, Federica Furlan, Daniela Arpa, Giovanni Grami, Oneda Guerini, Camilla Riboni, Roberta Mastracci, Luca Di Sabatino, Antonio |
author_facet | Vanoli, Alessandro Grillo, Federica Furlan, Daniela Arpa, Giovanni Grami, Oneda Guerini, Camilla Riboni, Roberta Mastracci, Luca Di Sabatino, Antonio |
author_sort | Vanoli, Alessandro |
collection | PubMed |
description | The wider use of gastrointestinal endoscopic procedures has led to an increased detection of small intestinal preneoplastic and neoplastic epithelial lesions, most of which are identified in the duodenum and ampullary region. Like their malignant counterparts, small intestinal glandular precursor lesions, which include adenomas and hamartomas, may arise sporadically or be associated with hereditary tumor syndromes, such as familial adenomatous polyposis, MUTYH-associated polyposis, Lynch syndrome, Peutz-Jeghers syndrome, juvenile polyposis syndrome, and Cowden syndrome. In addition, dysplastic, preinvasive lesions have been observed adjacent to small bowel adenocarcinomas complicating immune-related disorders, such as celiac or Crohn’s disease. Adenomatous lesions may exhibit an intestinal-type, gastric-type, or, very rarely, serrated differentiation, related to different molecular pathogenetic mechanisms. Finally, in the background of multiple endocrine neoplasia 1 syndrome, precursor neuroendocrine growths have been described. In this review we offer a comprehensive description on the histo-molecular features of the main histotypes of small bowel epithelial precursors lesions, including: (i) sporadic adenomas (intestinal-type and gastric-type; non-ampullary and ampullary); (ii) syndromic adenomas; (iii) small bowel dysplasia in celiac and Crohn’s disease; (iv) serrated lesions; (v) hamartomatous lesions; and (vi) neuroendocrine precursor lesions. |
format | Online Article Text |
id | pubmed-8122855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81228552021-05-16 Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations Vanoli, Alessandro Grillo, Federica Furlan, Daniela Arpa, Giovanni Grami, Oneda Guerini, Camilla Riboni, Roberta Mastracci, Luca Di Sabatino, Antonio Int J Mol Sci Review The wider use of gastrointestinal endoscopic procedures has led to an increased detection of small intestinal preneoplastic and neoplastic epithelial lesions, most of which are identified in the duodenum and ampullary region. Like their malignant counterparts, small intestinal glandular precursor lesions, which include adenomas and hamartomas, may arise sporadically or be associated with hereditary tumor syndromes, such as familial adenomatous polyposis, MUTYH-associated polyposis, Lynch syndrome, Peutz-Jeghers syndrome, juvenile polyposis syndrome, and Cowden syndrome. In addition, dysplastic, preinvasive lesions have been observed adjacent to small bowel adenocarcinomas complicating immune-related disorders, such as celiac or Crohn’s disease. Adenomatous lesions may exhibit an intestinal-type, gastric-type, or, very rarely, serrated differentiation, related to different molecular pathogenetic mechanisms. Finally, in the background of multiple endocrine neoplasia 1 syndrome, precursor neuroendocrine growths have been described. In this review we offer a comprehensive description on the histo-molecular features of the main histotypes of small bowel epithelial precursors lesions, including: (i) sporadic adenomas (intestinal-type and gastric-type; non-ampullary and ampullary); (ii) syndromic adenomas; (iii) small bowel dysplasia in celiac and Crohn’s disease; (iv) serrated lesions; (v) hamartomatous lesions; and (vi) neuroendocrine precursor lesions. MDPI 2021-04-22 /pmc/articles/PMC8122855/ /pubmed/33922305 http://dx.doi.org/10.3390/ijms22094388 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vanoli, Alessandro Grillo, Federica Furlan, Daniela Arpa, Giovanni Grami, Oneda Guerini, Camilla Riboni, Roberta Mastracci, Luca Di Sabatino, Antonio Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations |
title | Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations |
title_full | Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations |
title_fullStr | Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations |
title_full_unstemmed | Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations |
title_short | Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations |
title_sort | small bowel epithelial precursor lesions: a focus on molecular alterations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122855/ https://www.ncbi.nlm.nih.gov/pubmed/33922305 http://dx.doi.org/10.3390/ijms22094388 |
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