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Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations

The wider use of gastrointestinal endoscopic procedures has led to an increased detection of small intestinal preneoplastic and neoplastic epithelial lesions, most of which are identified in the duodenum and ampullary region. Like their malignant counterparts, small intestinal glandular precursor le...

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Autores principales: Vanoli, Alessandro, Grillo, Federica, Furlan, Daniela, Arpa, Giovanni, Grami, Oneda, Guerini, Camilla, Riboni, Roberta, Mastracci, Luca, Di Sabatino, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122855/
https://www.ncbi.nlm.nih.gov/pubmed/33922305
http://dx.doi.org/10.3390/ijms22094388
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author Vanoli, Alessandro
Grillo, Federica
Furlan, Daniela
Arpa, Giovanni
Grami, Oneda
Guerini, Camilla
Riboni, Roberta
Mastracci, Luca
Di Sabatino, Antonio
author_facet Vanoli, Alessandro
Grillo, Federica
Furlan, Daniela
Arpa, Giovanni
Grami, Oneda
Guerini, Camilla
Riboni, Roberta
Mastracci, Luca
Di Sabatino, Antonio
author_sort Vanoli, Alessandro
collection PubMed
description The wider use of gastrointestinal endoscopic procedures has led to an increased detection of small intestinal preneoplastic and neoplastic epithelial lesions, most of which are identified in the duodenum and ampullary region. Like their malignant counterparts, small intestinal glandular precursor lesions, which include adenomas and hamartomas, may arise sporadically or be associated with hereditary tumor syndromes, such as familial adenomatous polyposis, MUTYH-associated polyposis, Lynch syndrome, Peutz-Jeghers syndrome, juvenile polyposis syndrome, and Cowden syndrome. In addition, dysplastic, preinvasive lesions have been observed adjacent to small bowel adenocarcinomas complicating immune-related disorders, such as celiac or Crohn’s disease. Adenomatous lesions may exhibit an intestinal-type, gastric-type, or, very rarely, serrated differentiation, related to different molecular pathogenetic mechanisms. Finally, in the background of multiple endocrine neoplasia 1 syndrome, precursor neuroendocrine growths have been described. In this review we offer a comprehensive description on the histo-molecular features of the main histotypes of small bowel epithelial precursors lesions, including: (i) sporadic adenomas (intestinal-type and gastric-type; non-ampullary and ampullary); (ii) syndromic adenomas; (iii) small bowel dysplasia in celiac and Crohn’s disease; (iv) serrated lesions; (v) hamartomatous lesions; and (vi) neuroendocrine precursor lesions.
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spelling pubmed-81228552021-05-16 Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations Vanoli, Alessandro Grillo, Federica Furlan, Daniela Arpa, Giovanni Grami, Oneda Guerini, Camilla Riboni, Roberta Mastracci, Luca Di Sabatino, Antonio Int J Mol Sci Review The wider use of gastrointestinal endoscopic procedures has led to an increased detection of small intestinal preneoplastic and neoplastic epithelial lesions, most of which are identified in the duodenum and ampullary region. Like their malignant counterparts, small intestinal glandular precursor lesions, which include adenomas and hamartomas, may arise sporadically or be associated with hereditary tumor syndromes, such as familial adenomatous polyposis, MUTYH-associated polyposis, Lynch syndrome, Peutz-Jeghers syndrome, juvenile polyposis syndrome, and Cowden syndrome. In addition, dysplastic, preinvasive lesions have been observed adjacent to small bowel adenocarcinomas complicating immune-related disorders, such as celiac or Crohn’s disease. Adenomatous lesions may exhibit an intestinal-type, gastric-type, or, very rarely, serrated differentiation, related to different molecular pathogenetic mechanisms. Finally, in the background of multiple endocrine neoplasia 1 syndrome, precursor neuroendocrine growths have been described. In this review we offer a comprehensive description on the histo-molecular features of the main histotypes of small bowel epithelial precursors lesions, including: (i) sporadic adenomas (intestinal-type and gastric-type; non-ampullary and ampullary); (ii) syndromic adenomas; (iii) small bowel dysplasia in celiac and Crohn’s disease; (iv) serrated lesions; (v) hamartomatous lesions; and (vi) neuroendocrine precursor lesions. MDPI 2021-04-22 /pmc/articles/PMC8122855/ /pubmed/33922305 http://dx.doi.org/10.3390/ijms22094388 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vanoli, Alessandro
Grillo, Federica
Furlan, Daniela
Arpa, Giovanni
Grami, Oneda
Guerini, Camilla
Riboni, Roberta
Mastracci, Luca
Di Sabatino, Antonio
Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations
title Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations
title_full Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations
title_fullStr Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations
title_full_unstemmed Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations
title_short Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations
title_sort small bowel epithelial precursor lesions: a focus on molecular alterations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122855/
https://www.ncbi.nlm.nih.gov/pubmed/33922305
http://dx.doi.org/10.3390/ijms22094388
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