SGLT2is and Renal Protection: From Biological Mechanisms to Real-World Clinical Benefits

In recent years, following the publication of results from several RCTs, first on cardiovascular and more recently on renal outcomes, SGLT2is have become the standard of care to prevent diabetic kidney disease and slow its progression. This narrative review focuses on biological mechanisms, both ren...

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Autores principales: Leoncini, Giovanna, Russo, Elisa, Bussalino, Elisabetta, Barnini, Cecilia, Viazzi, Francesca, Pontremoli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122991/
https://www.ncbi.nlm.nih.gov/pubmed/33922865
http://dx.doi.org/10.3390/ijms22094441
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author Leoncini, Giovanna
Russo, Elisa
Bussalino, Elisabetta
Barnini, Cecilia
Viazzi, Francesca
Pontremoli, Roberto
author_facet Leoncini, Giovanna
Russo, Elisa
Bussalino, Elisabetta
Barnini, Cecilia
Viazzi, Francesca
Pontremoli, Roberto
author_sort Leoncini, Giovanna
collection PubMed
description In recent years, following the publication of results from several RCTs, first on cardiovascular and more recently on renal outcomes, SGLT2is have become the standard of care to prevent diabetic kidney disease and slow its progression. This narrative review focuses on biological mechanisms, both renal and extrarenal, underlying kidney protection with SGLT2is. Furthermore, data from cardiovascular as well as renal outcome trials, mostly conducted in diabetic patients, are presented and discussed to provide an overview of current uses as well as the future therapeutic potential of these drugs.
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spelling pubmed-81229912021-05-16 SGLT2is and Renal Protection: From Biological Mechanisms to Real-World Clinical Benefits Leoncini, Giovanna Russo, Elisa Bussalino, Elisabetta Barnini, Cecilia Viazzi, Francesca Pontremoli, Roberto Int J Mol Sci Review In recent years, following the publication of results from several RCTs, first on cardiovascular and more recently on renal outcomes, SGLT2is have become the standard of care to prevent diabetic kidney disease and slow its progression. This narrative review focuses on biological mechanisms, both renal and extrarenal, underlying kidney protection with SGLT2is. Furthermore, data from cardiovascular as well as renal outcome trials, mostly conducted in diabetic patients, are presented and discussed to provide an overview of current uses as well as the future therapeutic potential of these drugs. MDPI 2021-04-23 /pmc/articles/PMC8122991/ /pubmed/33922865 http://dx.doi.org/10.3390/ijms22094441 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Leoncini, Giovanna
Russo, Elisa
Bussalino, Elisabetta
Barnini, Cecilia
Viazzi, Francesca
Pontremoli, Roberto
SGLT2is and Renal Protection: From Biological Mechanisms to Real-World Clinical Benefits
title SGLT2is and Renal Protection: From Biological Mechanisms to Real-World Clinical Benefits
title_full SGLT2is and Renal Protection: From Biological Mechanisms to Real-World Clinical Benefits
title_fullStr SGLT2is and Renal Protection: From Biological Mechanisms to Real-World Clinical Benefits
title_full_unstemmed SGLT2is and Renal Protection: From Biological Mechanisms to Real-World Clinical Benefits
title_short SGLT2is and Renal Protection: From Biological Mechanisms to Real-World Clinical Benefits
title_sort sglt2is and renal protection: from biological mechanisms to real-world clinical benefits
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122991/
https://www.ncbi.nlm.nih.gov/pubmed/33922865
http://dx.doi.org/10.3390/ijms22094441
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