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Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study
PURPOSE: The aim of our study was to identify the diagnostic ability of free fatty acids (FFAs) in younger colorectal cancer (CRC) patients by comparing carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). METHODS: Patients screened for CRC at Fujian Medical University Union Hospit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123087/ https://www.ncbi.nlm.nih.gov/pubmed/34007210 http://dx.doi.org/10.2147/CMAR.S307753 |
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author | Zhu, Bin Zhang, Junrong Zheng, Qingzhu Dong, Binhua Wang, Meihua Liu, Jin Cao, Yingping |
author_facet | Zhu, Bin Zhang, Junrong Zheng, Qingzhu Dong, Binhua Wang, Meihua Liu, Jin Cao, Yingping |
author_sort | Zhu, Bin |
collection | PubMed |
description | PURPOSE: The aim of our study was to identify the diagnostic ability of free fatty acids (FFAs) in younger colorectal cancer (CRC) patients by comparing carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). METHODS: Patients screened for CRC at Fujian Medical University Union Hospital from January 2011 to December 2014 were recruited. Patients pathologically diagnosed with CRC or colorectal adenoma (CA) and healthy control participants were included. The enzyme endpoint method was applied to measure FFA levels. Receiver operating characteristic (ROC) curve analysis was performed to further evaluate the diagnostic ability of FFAs. RESULTS: FFA levels in late-stage patients (tumour-node-metastasis (TNM) stages III–IV) were higher than those in early-stage patients (TNM stages I–II) (P=0.02). The FFA levels in CRC patients were higher than those in controls of all ages, those younger than 50 years, males and females (P<0.001), and this difference was larger for patients younger than 50 years and females than for the all ages group. There was no significant difference in the FFA level between CA patients and healthy participants (P=0.53). The area under the curve (AUC) values of FFA, CEA, CA19-9, FFA+CEA, FFA+CA19-9 and FFA+CEA+CA19-9 distinguished CRC patients from controls at all ages, with values of 0.604, 0.731, 0.640, 0.754, 0.678 and 0.758, respectively; however, in the younger CRC patients (age≤50), the AUC values were 0.701, 0.735, 0.669, 0.798, 0.749, and 0.801. The AUC in female patients younger than 50 years was larger than that in males (0.769 vs 0.660), and this value was greater than the value for CEA in males (0.739) and females (0.729). CONCLUSION: The FFA level not only can complement the predictive ability of the CEA and CA19-9 levels but also has a superior predictive ability in female and younger patients with CRC. FFA levels may have a potential role in triage screening of early CRC. |
format | Online Article Text |
id | pubmed-8123087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-81230872021-05-17 Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study Zhu, Bin Zhang, Junrong Zheng, Qingzhu Dong, Binhua Wang, Meihua Liu, Jin Cao, Yingping Cancer Manag Res Original Research PURPOSE: The aim of our study was to identify the diagnostic ability of free fatty acids (FFAs) in younger colorectal cancer (CRC) patients by comparing carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). METHODS: Patients screened for CRC at Fujian Medical University Union Hospital from January 2011 to December 2014 were recruited. Patients pathologically diagnosed with CRC or colorectal adenoma (CA) and healthy control participants were included. The enzyme endpoint method was applied to measure FFA levels. Receiver operating characteristic (ROC) curve analysis was performed to further evaluate the diagnostic ability of FFAs. RESULTS: FFA levels in late-stage patients (tumour-node-metastasis (TNM) stages III–IV) were higher than those in early-stage patients (TNM stages I–II) (P=0.02). The FFA levels in CRC patients were higher than those in controls of all ages, those younger than 50 years, males and females (P<0.001), and this difference was larger for patients younger than 50 years and females than for the all ages group. There was no significant difference in the FFA level between CA patients and healthy participants (P=0.53). The area under the curve (AUC) values of FFA, CEA, CA19-9, FFA+CEA, FFA+CA19-9 and FFA+CEA+CA19-9 distinguished CRC patients from controls at all ages, with values of 0.604, 0.731, 0.640, 0.754, 0.678 and 0.758, respectively; however, in the younger CRC patients (age≤50), the AUC values were 0.701, 0.735, 0.669, 0.798, 0.749, and 0.801. The AUC in female patients younger than 50 years was larger than that in males (0.769 vs 0.660), and this value was greater than the value for CEA in males (0.739) and females (0.729). CONCLUSION: The FFA level not only can complement the predictive ability of the CEA and CA19-9 levels but also has a superior predictive ability in female and younger patients with CRC. FFA levels may have a potential role in triage screening of early CRC. Dove 2021-05-10 /pmc/articles/PMC8123087/ /pubmed/34007210 http://dx.doi.org/10.2147/CMAR.S307753 Text en © 2021 Zhu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Zhu, Bin Zhang, Junrong Zheng, Qingzhu Dong, Binhua Wang, Meihua Liu, Jin Cao, Yingping Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study |
title | Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study |
title_full | Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study |
title_fullStr | Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study |
title_full_unstemmed | Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study |
title_short | Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study |
title_sort | free fatty acid is a promising biomarker in triage screening for patients with colorectal cancer: a case–control study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123087/ https://www.ncbi.nlm.nih.gov/pubmed/34007210 http://dx.doi.org/10.2147/CMAR.S307753 |
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