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A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis

Foreign body giant cell (FBGC) reaction to silicone material in the lymph nodes of patients with silicone breast implants has been documented in the literature, with a number of case reports dating back to 1978. Many of these case reports describe histologic features of silicone lymphadenopathy in r...

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Autores principales: Todorov, Todor I., de Bakker, Erik, Smith, Diane, Langenberg, Lisette C., Murakata, Linda A., Kramer, Mark H. H., Centeno, Jose A., Nanayakkara, Prabath W. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123188/
https://www.ncbi.nlm.nih.gov/pubmed/33923240
http://dx.doi.org/10.3390/ijerph18094526
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author Todorov, Todor I.
de Bakker, Erik
Smith, Diane
Langenberg, Lisette C.
Murakata, Linda A.
Kramer, Mark H. H.
Centeno, Jose A.
Nanayakkara, Prabath W. B.
author_facet Todorov, Todor I.
de Bakker, Erik
Smith, Diane
Langenberg, Lisette C.
Murakata, Linda A.
Kramer, Mark H. H.
Centeno, Jose A.
Nanayakkara, Prabath W. B.
author_sort Todorov, Todor I.
collection PubMed
description Foreign body giant cell (FBGC) reaction to silicone material in the lymph nodes of patients with silicone breast implants has been documented in the literature, with a number of case reports dating back to 1978. Many of these case reports describe histologic features of silicone lymphadenopathy in regional lymph nodes from patients with multiple sets of different types of implants, including single lumen smooth surface gel, single lumen textured surface gel, single lumen with polyethylene terephthalate patch, single lumen with polyurethane coating, and double lumen smooth surface. Only one other case report described a patient with highly-cohesive breast implants and silicone granulomas of the skin. In this article, we describe a patient with a clinical presentation of systemic sarcoidosis following highly cohesive breast implant placement. Histopathologic analysis and Confocal Laser Raman Microprobe (CLRM) examination were used to confirm the presence of silicone in the axillary lymph node and capsular tissues. This is the first report where chemical spectroscopic mapping has been used to establish and identify the coexistence of Schaumann bodies, consisting of calcium oxalate and calcium phosphate minerals, together with silicone implant material.
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spelling pubmed-81231882021-05-16 A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis Todorov, Todor I. de Bakker, Erik Smith, Diane Langenberg, Lisette C. Murakata, Linda A. Kramer, Mark H. H. Centeno, Jose A. Nanayakkara, Prabath W. B. Int J Environ Res Public Health Article Foreign body giant cell (FBGC) reaction to silicone material in the lymph nodes of patients with silicone breast implants has been documented in the literature, with a number of case reports dating back to 1978. Many of these case reports describe histologic features of silicone lymphadenopathy in regional lymph nodes from patients with multiple sets of different types of implants, including single lumen smooth surface gel, single lumen textured surface gel, single lumen with polyethylene terephthalate patch, single lumen with polyurethane coating, and double lumen smooth surface. Only one other case report described a patient with highly-cohesive breast implants and silicone granulomas of the skin. In this article, we describe a patient with a clinical presentation of systemic sarcoidosis following highly cohesive breast implant placement. Histopathologic analysis and Confocal Laser Raman Microprobe (CLRM) examination were used to confirm the presence of silicone in the axillary lymph node and capsular tissues. This is the first report where chemical spectroscopic mapping has been used to establish and identify the coexistence of Schaumann bodies, consisting of calcium oxalate and calcium phosphate minerals, together with silicone implant material. MDPI 2021-04-24 /pmc/articles/PMC8123188/ /pubmed/33923240 http://dx.doi.org/10.3390/ijerph18094526 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Todorov, Todor I.
de Bakker, Erik
Smith, Diane
Langenberg, Lisette C.
Murakata, Linda A.
Kramer, Mark H. H.
Centeno, Jose A.
Nanayakkara, Prabath W. B.
A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis
title A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis
title_full A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis
title_fullStr A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis
title_full_unstemmed A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis
title_short A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis
title_sort case of silicone and sarcoid granulomas in a patient with “highly cohesive” silicone breast implants: a histopathologic and laser raman microprobe analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123188/
https://www.ncbi.nlm.nih.gov/pubmed/33923240
http://dx.doi.org/10.3390/ijerph18094526
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