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The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma
The development and effectiveness of novel therapies in multiple myeloma have been established in large clinical trials. However, multiple myeloma remains an incurable malignancy despite significant therapeutic advances. Accumulating data have elucidated our understanding of the genetic background o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123209/ https://www.ncbi.nlm.nih.gov/pubmed/33923357 http://dx.doi.org/10.3390/ijms22094462 |
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author | Giannakoulas, Nikolaos Ntanasis-Stathopoulos, Ioannis Terpos, Evangelos |
author_facet | Giannakoulas, Nikolaos Ntanasis-Stathopoulos, Ioannis Terpos, Evangelos |
author_sort | Giannakoulas, Nikolaos |
collection | PubMed |
description | The development and effectiveness of novel therapies in multiple myeloma have been established in large clinical trials. However, multiple myeloma remains an incurable malignancy despite significant therapeutic advances. Accumulating data have elucidated our understanding of the genetic background of the malignant plasma cells along with the role of the bone marrow microenvironment. Currently, the interaction among myeloma cells and the components of the microenvironment are considered crucial in multiple myeloma pathogenesis. Adhesion molecules, cytokines and the extracellular matrix play a critical role in the interplay among genetically transformed clonal plasma cells and stromal cells, leading to the proliferation, progression and survival of myeloma cells. In this review, we provide an overview of the multifaceted role of the bone marrow microenvironment in the growth and development of malignant plasma cells in multiple myeloma. |
format | Online Article Text |
id | pubmed-8123209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81232092021-05-16 The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma Giannakoulas, Nikolaos Ntanasis-Stathopoulos, Ioannis Terpos, Evangelos Int J Mol Sci Review The development and effectiveness of novel therapies in multiple myeloma have been established in large clinical trials. However, multiple myeloma remains an incurable malignancy despite significant therapeutic advances. Accumulating data have elucidated our understanding of the genetic background of the malignant plasma cells along with the role of the bone marrow microenvironment. Currently, the interaction among myeloma cells and the components of the microenvironment are considered crucial in multiple myeloma pathogenesis. Adhesion molecules, cytokines and the extracellular matrix play a critical role in the interplay among genetically transformed clonal plasma cells and stromal cells, leading to the proliferation, progression and survival of myeloma cells. In this review, we provide an overview of the multifaceted role of the bone marrow microenvironment in the growth and development of malignant plasma cells in multiple myeloma. MDPI 2021-04-24 /pmc/articles/PMC8123209/ /pubmed/33923357 http://dx.doi.org/10.3390/ijms22094462 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Giannakoulas, Nikolaos Ntanasis-Stathopoulos, Ioannis Terpos, Evangelos The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma |
title | The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma |
title_full | The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma |
title_fullStr | The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma |
title_full_unstemmed | The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma |
title_short | The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma |
title_sort | role of marrow microenvironment in the growth and development of malignant plasma cells in multiple myeloma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123209/ https://www.ncbi.nlm.nih.gov/pubmed/33923357 http://dx.doi.org/10.3390/ijms22094462 |
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