Predicting Absorption-Distribution Properties of Neuroprotective Phosphine-Borane Compounds Using In Silico Modeling and Machine Learning

Phosphine-borane complexes are novel chemical entities with preclinical efficacy in neuronal and ophthalmic disease models. In vitro and in vivo studies showed that the metabolites of these compounds are capable of cleaving disulfide bonds implicated in the downstream effects of axonal injury. A dif...

Descripción completa

Detalles Bibliográficos
Autores principales: Remtulla, Raheem, Das, Sanjoy Kumar, Levin, Leonard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123347/
https://www.ncbi.nlm.nih.gov/pubmed/33923006
http://dx.doi.org/10.3390/molecules26092505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123347/
https://www.ncbi.nlm.nih.gov/pubmed/33923006
http://dx.doi.org/10.3390/molecules26092505

Ejemplares similares