The emerging role of cellular senescence in complications of COVID-19

The coronavirus disease 2019 (COVID-19) pandemic has triggered a sudden global change in healthcare systems. Cancer patients have a higher risk of death from COVID-19 in comparison to patients without cancer. Many studies have stated that various factors, such as older age, frequent exposure to heal...

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Detalles Bibliográficos
Autores principales: Mohiuddin, Md, Kasahara, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123375/
https://www.ncbi.nlm.nih.gov/pubmed/34023769
http://dx.doi.org/10.1016/j.ctarc.2021.100399
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author Mohiuddin, Md
Kasahara, Kazuo
author_facet Mohiuddin, Md
Kasahara, Kazuo
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description The coronavirus disease 2019 (COVID-19) pandemic has triggered a sudden global change in healthcare systems. Cancer patients have a higher risk of death from COVID-19 in comparison to patients without cancer. Many studies have stated that various factors, such as older age, frequent exposure to healthcare, and higher smoking rates are responsible for the complications of COVID-19. We hypothesize that side effects of chemotherapy, such as cellular senescence, could worsen COVID-19. Given this situation, in this review, we highlight the updated findings of research investigating the impact of cellular senescence on COVID-19 complications and explored potential therapeutic targets for eliminating senescent cells during the COVID-19 pandemic.
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spelling pubmed-81233752021-05-17 The emerging role of cellular senescence in complications of COVID-19 Mohiuddin, Md Kasahara, Kazuo Cancer Treat Res Commun Review Article The coronavirus disease 2019 (COVID-19) pandemic has triggered a sudden global change in healthcare systems. Cancer patients have a higher risk of death from COVID-19 in comparison to patients without cancer. Many studies have stated that various factors, such as older age, frequent exposure to healthcare, and higher smoking rates are responsible for the complications of COVID-19. We hypothesize that side effects of chemotherapy, such as cellular senescence, could worsen COVID-19. Given this situation, in this review, we highlight the updated findings of research investigating the impact of cellular senescence on COVID-19 complications and explored potential therapeutic targets for eliminating senescent cells during the COVID-19 pandemic. The Author(s). Published by Elsevier Ltd. 2021 2021-05-15 /pmc/articles/PMC8123375/ /pubmed/34023769 http://dx.doi.org/10.1016/j.ctarc.2021.100399 Text en © 2021 The Author(s). Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Mohiuddin, Md
Kasahara, Kazuo
The emerging role of cellular senescence in complications of COVID-19
title The emerging role of cellular senescence in complications of COVID-19
title_full The emerging role of cellular senescence in complications of COVID-19
title_fullStr The emerging role of cellular senescence in complications of COVID-19
title_full_unstemmed The emerging role of cellular senescence in complications of COVID-19
title_short The emerging role of cellular senescence in complications of COVID-19
title_sort emerging role of cellular senescence in complications of covid-19
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123375/
https://www.ncbi.nlm.nih.gov/pubmed/34023769
http://dx.doi.org/10.1016/j.ctarc.2021.100399
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