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The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development

In 2018, 550,000 people were diagnosed with bladder cancer (BC), of which nearly 200,000 people died. Moreover, men are 4 times more likely than women to be diagnosed with BC. The risk factors include exposure to environmental and occupational chemicals, especially tobacco smoke, benzidine and genet...

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Autores principales: Wigner, Paulina, Grębowski, Radosław, Bijak, Michał, Saluk-Bijak, Joanna, Szemraj, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123426/
https://www.ncbi.nlm.nih.gov/pubmed/33923108
http://dx.doi.org/10.3390/ijms22094483
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author Wigner, Paulina
Grębowski, Radosław
Bijak, Michał
Saluk-Bijak, Joanna
Szemraj, Janusz
author_facet Wigner, Paulina
Grębowski, Radosław
Bijak, Michał
Saluk-Bijak, Joanna
Szemraj, Janusz
author_sort Wigner, Paulina
collection PubMed
description In 2018, 550,000 people were diagnosed with bladder cancer (BC), of which nearly 200,000 people died. Moreover, men are 4 times more likely than women to be diagnosed with BC. The risk factors include exposure to environmental and occupational chemicals, especially tobacco smoke, benzidine and genetic factors. Despite numerous studies, the molecular basis of BC development remains unclear. A growing body of evidence suggests that inflammation, oxidant-antioxidant imbalance and angiogenesis disorders may play a significant role in the development and progression of bladder cancer. The patients with bladder cancer were characterised by an increased level of reactive oxygen species (ROS), the products of lipid peroxidation, proinflammatory cytokines and proangiogenic factors as compared to controls. Furthermore, it was shown that polymorphisms localised in genes associated with these pathways may modulate the risk of BC. Interestingly, ROS overproduction may induce the production of proinflammatory cytokines, which finally activated angiogenesis. Moreover, the available literature shows that both inflammation and oxidative stress may lead to activation of angiogenesis and tumour progression in BC patients.
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spelling pubmed-81234262021-05-16 The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development Wigner, Paulina Grębowski, Radosław Bijak, Michał Saluk-Bijak, Joanna Szemraj, Janusz Int J Mol Sci Review In 2018, 550,000 people were diagnosed with bladder cancer (BC), of which nearly 200,000 people died. Moreover, men are 4 times more likely than women to be diagnosed with BC. The risk factors include exposure to environmental and occupational chemicals, especially tobacco smoke, benzidine and genetic factors. Despite numerous studies, the molecular basis of BC development remains unclear. A growing body of evidence suggests that inflammation, oxidant-antioxidant imbalance and angiogenesis disorders may play a significant role in the development and progression of bladder cancer. The patients with bladder cancer were characterised by an increased level of reactive oxygen species (ROS), the products of lipid peroxidation, proinflammatory cytokines and proangiogenic factors as compared to controls. Furthermore, it was shown that polymorphisms localised in genes associated with these pathways may modulate the risk of BC. Interestingly, ROS overproduction may induce the production of proinflammatory cytokines, which finally activated angiogenesis. Moreover, the available literature shows that both inflammation and oxidative stress may lead to activation of angiogenesis and tumour progression in BC patients. MDPI 2021-04-25 /pmc/articles/PMC8123426/ /pubmed/33923108 http://dx.doi.org/10.3390/ijms22094483 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wigner, Paulina
Grębowski, Radosław
Bijak, Michał
Saluk-Bijak, Joanna
Szemraj, Janusz
The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development
title The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development
title_full The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development
title_fullStr The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development
title_full_unstemmed The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development
title_short The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development
title_sort interplay between oxidative stress, inflammation and angiogenesis in bladder cancer development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123426/
https://www.ncbi.nlm.nih.gov/pubmed/33923108
http://dx.doi.org/10.3390/ijms22094483
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