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Autoinflammatory Features in Gouty Arthritis
In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation provoke crystal deposits in joints. However, since hyperuricemia alone is not sufficient to develop gout, molecular-genetic c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123608/ https://www.ncbi.nlm.nih.gov/pubmed/33926105 http://dx.doi.org/10.3390/jcm10091880 |
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author | Galozzi, Paola Bindoli, Sara Doria, Andrea Oliviero, Francesca Sfriso, Paolo |
author_facet | Galozzi, Paola Bindoli, Sara Doria, Andrea Oliviero, Francesca Sfriso, Paolo |
author_sort | Galozzi, Paola |
collection | PubMed |
description | In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation provoke crystal deposits in joints. However, since hyperuricemia alone is not sufficient to develop gout, molecular-genetic contributions are necessary to better clinically frame the disease. Herein, we review the autoinflammatory features of gout, from clinical challenges and differential diagnosis, to the autoinflammatory mechanisms, providing also emerging therapeutic options available for targeting the main inflammatory pathways involved in gout pathogenesis. This has important implication as treating the autoinflammatory aspects and not only the dysmetabolic side of gout may provide an effective and safer alternative for patients even in the prevention of possible gouty attacks. |
format | Online Article Text |
id | pubmed-8123608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81236082021-05-16 Autoinflammatory Features in Gouty Arthritis Galozzi, Paola Bindoli, Sara Doria, Andrea Oliviero, Francesca Sfriso, Paolo J Clin Med Review In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation provoke crystal deposits in joints. However, since hyperuricemia alone is not sufficient to develop gout, molecular-genetic contributions are necessary to better clinically frame the disease. Herein, we review the autoinflammatory features of gout, from clinical challenges and differential diagnosis, to the autoinflammatory mechanisms, providing also emerging therapeutic options available for targeting the main inflammatory pathways involved in gout pathogenesis. This has important implication as treating the autoinflammatory aspects and not only the dysmetabolic side of gout may provide an effective and safer alternative for patients even in the prevention of possible gouty attacks. MDPI 2021-04-26 /pmc/articles/PMC8123608/ /pubmed/33926105 http://dx.doi.org/10.3390/jcm10091880 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Galozzi, Paola Bindoli, Sara Doria, Andrea Oliviero, Francesca Sfriso, Paolo Autoinflammatory Features in Gouty Arthritis |
title | Autoinflammatory Features in Gouty Arthritis |
title_full | Autoinflammatory Features in Gouty Arthritis |
title_fullStr | Autoinflammatory Features in Gouty Arthritis |
title_full_unstemmed | Autoinflammatory Features in Gouty Arthritis |
title_short | Autoinflammatory Features in Gouty Arthritis |
title_sort | autoinflammatory features in gouty arthritis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123608/ https://www.ncbi.nlm.nih.gov/pubmed/33926105 http://dx.doi.org/10.3390/jcm10091880 |
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